Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae

Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidias...

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Autores principales: Fredericks, Lance R., Lee, Mark D., Eckert, Hannah R., Li, Shunji, Shipley, Mason A., Roslund, Cooper R., Boikov, Dina A., Kizer, Emily A., Sobel, Jack D., Rowley, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218651/
https://www.ncbi.nlm.nih.gov/pubmed/33972245
http://dx.doi.org/10.1128/AAC.02450-20
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author Fredericks, Lance R.
Lee, Mark D.
Eckert, Hannah R.
Li, Shunji
Shipley, Mason A.
Roslund, Cooper R.
Boikov, Dina A.
Kizer, Emily A.
Sobel, Jack D.
Rowley, Paul A.
author_facet Fredericks, Lance R.
Lee, Mark D.
Eckert, Hannah R.
Li, Shunji
Shipley, Mason A.
Roslund, Cooper R.
Boikov, Dina A.
Kizer, Emily A.
Sobel, Jack D.
Rowley, Paul A.
author_sort Fredericks, Lance R.
collection PubMed
description Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.
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spelling pubmed-82186512021-12-17 Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae Fredericks, Lance R. Lee, Mark D. Eckert, Hannah R. Li, Shunji Shipley, Mason A. Roslund, Cooper R. Boikov, Dina A. Kizer, Emily A. Sobel, Jack D. Rowley, Paul A. Antimicrob Agents Chemother Experimental Therapeutics Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics. American Society for Microbiology 2021-06-17 /pmc/articles/PMC8218651/ /pubmed/33972245 http://dx.doi.org/10.1128/AAC.02450-20 Text en Copyright © 2021 Fredericks et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Fredericks, Lance R.
Lee, Mark D.
Eckert, Hannah R.
Li, Shunji
Shipley, Mason A.
Roslund, Cooper R.
Boikov, Dina A.
Kizer, Emily A.
Sobel, Jack D.
Rowley, Paul A.
Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title_full Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title_fullStr Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title_full_unstemmed Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title_short Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
title_sort vaginal isolates of candida glabrata are uniquely susceptible to ionophoric killer toxins produced by saccharomyces cerevisiae
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218651/
https://www.ncbi.nlm.nih.gov/pubmed/33972245
http://dx.doi.org/10.1128/AAC.02450-20
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