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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian g...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219092/ https://www.ncbi.nlm.nih.gov/pubmed/34159328 http://dx.doi.org/10.1101/2021.06.16.448525 |
| _version_ | 1783710860639731712 |
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| author | Wuertz, Kathryn McGuckin Barkei, Erica K. Chen, Wei-Hung Martinez, Elizabeth J. Lakhal-Naouar, Ines Jagodzinski, Linda L. Paquin-Proulx, Dominic Gromowski, Gregory D. Swafford, Isabella Ganesh, Akshaya Dong, Ming Zeng, Xiankun Thomas, Paul V. Sankhala, Rajeshwer S. Hajduczki, Agnes Peterson, Caroline E. Kuklis, Caitlin Soman, Sandrine Wieczorek, Lindsay Zemil, Michelle Anderson, Alexander Darden, Janice Hernandez, Heather Grove, Hannah Dussupt, Vincent Hack, Holly de la Barrera, Rafael Zarling, Stasya Wood, James F. Froude, Jeffrey W. Gagne, Matthew Henry, Amy R. Mokhtari, Elham Bayat Mudvari, Prakriti Krebs, Shelly J. Pekosz, Andrew S. Currier, Jeffrey R. Kar, Swagata Porto, Maciel Winn, Adrienne Radzyminski, Kamil Lewis, Mark G. Vasan, Sandhya Suthar, Mehul Polonis, Victoria R. Matyas, Gary R. Boritz, Eli A. Douek, Daniel C. Seder, Robert A. Daye, Sharon P. Rao, Mangala Peel, Sheila A. Joyce, M. Gordon Bolton, Diane L. Michael, Nelson L. Modjarrad, Kayvon |
| author_facet | Wuertz, Kathryn McGuckin Barkei, Erica K. Chen, Wei-Hung Martinez, Elizabeth J. Lakhal-Naouar, Ines Jagodzinski, Linda L. Paquin-Proulx, Dominic Gromowski, Gregory D. Swafford, Isabella Ganesh, Akshaya Dong, Ming Zeng, Xiankun Thomas, Paul V. Sankhala, Rajeshwer S. Hajduczki, Agnes Peterson, Caroline E. Kuklis, Caitlin Soman, Sandrine Wieczorek, Lindsay Zemil, Michelle Anderson, Alexander Darden, Janice Hernandez, Heather Grove, Hannah Dussupt, Vincent Hack, Holly de la Barrera, Rafael Zarling, Stasya Wood, James F. Froude, Jeffrey W. Gagne, Matthew Henry, Amy R. Mokhtari, Elham Bayat Mudvari, Prakriti Krebs, Shelly J. Pekosz, Andrew S. Currier, Jeffrey R. Kar, Swagata Porto, Maciel Winn, Adrienne Radzyminski, Kamil Lewis, Mark G. Vasan, Sandhya Suthar, Mehul Polonis, Victoria R. Matyas, Gary R. Boritz, Eli A. Douek, Daniel C. Seder, Robert A. Daye, Sharon P. Rao, Mangala Peel, Sheila A. Joyce, M. Gordon Bolton, Diane L. Michael, Nelson L. Modjarrad, Kayvon |
| author_sort | Wuertz, Kathryn McGuckin |
| collection | PubMed |
| description | The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian golden hamsters. SpFN-ALFQ was administered as either single or double-vaccination (0 and 4 week) regimens, using a high (10 μg) or low (0.2 μg) immunogen dose. Animals were intranasally challenged at week 11. Binding antibody responses were comparable between high- and low-dose groups. Neutralizing antibody titers were equivalent against WA1, B.1.1.7, and B.1.351 variants following two high dose two vaccinations. SpFN-ALFQ vaccination protected against SARS-CoV-2-induced disease and viral replication following intranasal B.1.1.7 or B.1.351 challenge, as evidenced by reduced weight loss, lung pathology, and lung and nasal turbinate viral burden. These data support the development of SpFN-ALFQ as a broadly protective, next-generation SARS-CoV-2 vaccine. |
| format | Online Article Text |
| id | pubmed-8219092 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82190922021-06-23 A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters Wuertz, Kathryn McGuckin Barkei, Erica K. Chen, Wei-Hung Martinez, Elizabeth J. Lakhal-Naouar, Ines Jagodzinski, Linda L. Paquin-Proulx, Dominic Gromowski, Gregory D. Swafford, Isabella Ganesh, Akshaya Dong, Ming Zeng, Xiankun Thomas, Paul V. Sankhala, Rajeshwer S. Hajduczki, Agnes Peterson, Caroline E. Kuklis, Caitlin Soman, Sandrine Wieczorek, Lindsay Zemil, Michelle Anderson, Alexander Darden, Janice Hernandez, Heather Grove, Hannah Dussupt, Vincent Hack, Holly de la Barrera, Rafael Zarling, Stasya Wood, James F. Froude, Jeffrey W. Gagne, Matthew Henry, Amy R. Mokhtari, Elham Bayat Mudvari, Prakriti Krebs, Shelly J. Pekosz, Andrew S. Currier, Jeffrey R. Kar, Swagata Porto, Maciel Winn, Adrienne Radzyminski, Kamil Lewis, Mark G. Vasan, Sandhya Suthar, Mehul Polonis, Victoria R. Matyas, Gary R. Boritz, Eli A. Douek, Daniel C. Seder, Robert A. Daye, Sharon P. Rao, Mangala Peel, Sheila A. Joyce, M. Gordon Bolton, Diane L. Michael, Nelson L. Modjarrad, Kayvon bioRxiv Article The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian golden hamsters. SpFN-ALFQ was administered as either single or double-vaccination (0 and 4 week) regimens, using a high (10 μg) or low (0.2 μg) immunogen dose. Animals were intranasally challenged at week 11. Binding antibody responses were comparable between high- and low-dose groups. Neutralizing antibody titers were equivalent against WA1, B.1.1.7, and B.1.351 variants following two high dose two vaccinations. SpFN-ALFQ vaccination protected against SARS-CoV-2-induced disease and viral replication following intranasal B.1.1.7 or B.1.351 challenge, as evidenced by reduced weight loss, lung pathology, and lung and nasal turbinate viral burden. These data support the development of SpFN-ALFQ as a broadly protective, next-generation SARS-CoV-2 vaccine. Cold Spring Harbor Laboratory 2021-06-16 /pmc/articles/PMC8219092/ /pubmed/34159328 http://dx.doi.org/10.1101/2021.06.16.448525 Text en https://creativecommons.org/publicdomain/zero/1.0/This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license (https://creativecommons.org/publicdomain/zero/1.0/) . |
| spellingShingle | Article Wuertz, Kathryn McGuckin Barkei, Erica K. Chen, Wei-Hung Martinez, Elizabeth J. Lakhal-Naouar, Ines Jagodzinski, Linda L. Paquin-Proulx, Dominic Gromowski, Gregory D. Swafford, Isabella Ganesh, Akshaya Dong, Ming Zeng, Xiankun Thomas, Paul V. Sankhala, Rajeshwer S. Hajduczki, Agnes Peterson, Caroline E. Kuklis, Caitlin Soman, Sandrine Wieczorek, Lindsay Zemil, Michelle Anderson, Alexander Darden, Janice Hernandez, Heather Grove, Hannah Dussupt, Vincent Hack, Holly de la Barrera, Rafael Zarling, Stasya Wood, James F. Froude, Jeffrey W. Gagne, Matthew Henry, Amy R. Mokhtari, Elham Bayat Mudvari, Prakriti Krebs, Shelly J. Pekosz, Andrew S. Currier, Jeffrey R. Kar, Swagata Porto, Maciel Winn, Adrienne Radzyminski, Kamil Lewis, Mark G. Vasan, Sandhya Suthar, Mehul Polonis, Victoria R. Matyas, Gary R. Boritz, Eli A. Douek, Daniel C. Seder, Robert A. Daye, Sharon P. Rao, Mangala Peel, Sheila A. Joyce, M. Gordon Bolton, Diane L. Michael, Nelson L. Modjarrad, Kayvon A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title | A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title_full | A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title_fullStr | A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title_full_unstemmed | A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title_short | A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters |
| title_sort | sars-cov-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with b.1.1.7 and b.1.351 virus variants in syrian golden hamsters |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219092/ https://www.ncbi.nlm.nih.gov/pubmed/34159328 http://dx.doi.org/10.1101/2021.06.16.448525 |
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