A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian g...

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Detalles Bibliográficos
Autores principales: Wuertz, Kathryn McGuckin, Barkei, Erica K., Chen, Wei-Hung, Martinez, Elizabeth J., Lakhal-Naouar, Ines, Jagodzinski, Linda L., Paquin-Proulx, Dominic, Gromowski, Gregory D., Swafford, Isabella, Ganesh, Akshaya, Dong, Ming, Zeng, Xiankun, Thomas, Paul V., Sankhala, Rajeshwer S., Hajduczki, Agnes, Peterson, Caroline E., Kuklis, Caitlin, Soman, Sandrine, Wieczorek, Lindsay, Zemil, Michelle, Anderson, Alexander, Darden, Janice, Hernandez, Heather, Grove, Hannah, Dussupt, Vincent, Hack, Holly, de la Barrera, Rafael, Zarling, Stasya, Wood, James F., Froude, Jeffrey W., Gagne, Matthew, Henry, Amy R., Mokhtari, Elham Bayat, Mudvari, Prakriti, Krebs, Shelly J., Pekosz, Andrew S., Currier, Jeffrey R., Kar, Swagata, Porto, Maciel, Winn, Adrienne, Radzyminski, Kamil, Lewis, Mark G., Vasan, Sandhya, Suthar, Mehul, Polonis, Victoria R., Matyas, Gary R., Boritz, Eli A., Douek, Daniel C., Seder, Robert A., Daye, Sharon P., Rao, Mangala, Peel, Sheila A., Joyce, M. Gordon, Bolton, Diane L., Michael, Nelson L., Modjarrad, Kayvon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219092/
https://www.ncbi.nlm.nih.gov/pubmed/34159328
http://dx.doi.org/10.1101/2021.06.16.448525

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