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Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin accessibility and gene expression. Open chromatin re...

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Detalles Bibliográficos
Autores principales:	Hass, Matthew R., Brissette, Daniel, Parameswaran, Sreeja, Pujato, Mario, Donmez, Omer, Kottyan, Leah C., Weirauch, Matthew T., Kopan, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219162/ https://www.ncbi.nlm.nih.gov/pubmed/34111109 http://dx.doi.org/10.1371/journal.pgen.1009574

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