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An Examination of the Putative Role of Melatonin in Exosome Biogenesis

During the last two decades, melatonin has been found to have pleiotropic effects via different mechanisms on its target cells. Data are abundant for some aspects of the signaling pathways within cells while other casual mechanisms have not been adequately addressed. From an evolutionary perspective...

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Autores principales: Amini, Hassan, Rezabakhsh, Aysa, Heidarzadeh, Morteza, Hassanpour, Mehdi, Hashemzadeh, Shahriar, Ghaderi, Shahrouz, Sokullu, Emel, Rahbarghazi, Reza, Reiter, Russel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219171/
https://www.ncbi.nlm.nih.gov/pubmed/34169078
http://dx.doi.org/10.3389/fcell.2021.686551
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author Amini, Hassan
Rezabakhsh, Aysa
Heidarzadeh, Morteza
Hassanpour, Mehdi
Hashemzadeh, Shahriar
Ghaderi, Shahrouz
Sokullu, Emel
Rahbarghazi, Reza
Reiter, Russel J.
author_facet Amini, Hassan
Rezabakhsh, Aysa
Heidarzadeh, Morteza
Hassanpour, Mehdi
Hashemzadeh, Shahriar
Ghaderi, Shahrouz
Sokullu, Emel
Rahbarghazi, Reza
Reiter, Russel J.
author_sort Amini, Hassan
collection PubMed
description During the last two decades, melatonin has been found to have pleiotropic effects via different mechanisms on its target cells. Data are abundant for some aspects of the signaling pathways within cells while other casual mechanisms have not been adequately addressed. From an evolutionary perspective, eukaryotic cells are equipped with a set of interrelated endomembrane systems consisting of intracellular organelles and secretory vesicles. Of these, exosomes are touted as cargo-laden secretory vesicles that originate from the endosomal multivesicular machinery which participate in a mutual cross-talk at different cellular interfaces. It has been documented that cells transfer various biomolecules and genetic elements through exosomes to sites remote from the original cell in a paracrine manner. Findings related to the molecular mechanisms between melatonin and exosomal biogenesis and cargo sorting are the subject of the current review. The clarification of the interplay between melatonin and exosome biogenesis and cargo sorting at the molecular level will help to define a cell’s secretion capacity. This review precisely addresses the role and potential significance of melatonin in determining the efflux capacity of cells via the exosomal pathway. Certain cells, for example, stem cells actively increase exosome efflux in response to melatonin treatment which accelerates tissue regeneration after transplantation into the injured sites.
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spelling pubmed-82191712021-06-23 An Examination of the Putative Role of Melatonin in Exosome Biogenesis Amini, Hassan Rezabakhsh, Aysa Heidarzadeh, Morteza Hassanpour, Mehdi Hashemzadeh, Shahriar Ghaderi, Shahrouz Sokullu, Emel Rahbarghazi, Reza Reiter, Russel J. Front Cell Dev Biol Cell and Developmental Biology During the last two decades, melatonin has been found to have pleiotropic effects via different mechanisms on its target cells. Data are abundant for some aspects of the signaling pathways within cells while other casual mechanisms have not been adequately addressed. From an evolutionary perspective, eukaryotic cells are equipped with a set of interrelated endomembrane systems consisting of intracellular organelles and secretory vesicles. Of these, exosomes are touted as cargo-laden secretory vesicles that originate from the endosomal multivesicular machinery which participate in a mutual cross-talk at different cellular interfaces. It has been documented that cells transfer various biomolecules and genetic elements through exosomes to sites remote from the original cell in a paracrine manner. Findings related to the molecular mechanisms between melatonin and exosomal biogenesis and cargo sorting are the subject of the current review. The clarification of the interplay between melatonin and exosome biogenesis and cargo sorting at the molecular level will help to define a cell’s secretion capacity. This review precisely addresses the role and potential significance of melatonin in determining the efflux capacity of cells via the exosomal pathway. Certain cells, for example, stem cells actively increase exosome efflux in response to melatonin treatment which accelerates tissue regeneration after transplantation into the injured sites. Frontiers Media S.A. 2021-06-08 /pmc/articles/PMC8219171/ /pubmed/34169078 http://dx.doi.org/10.3389/fcell.2021.686551 Text en Copyright © 2021 Amini, Rezabakhsh, Heidarzadeh, Hassanpour, Hashemzadeh, Ghaderi, Sokullu, Rahbarghazi and Reiter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Amini, Hassan
Rezabakhsh, Aysa
Heidarzadeh, Morteza
Hassanpour, Mehdi
Hashemzadeh, Shahriar
Ghaderi, Shahrouz
Sokullu, Emel
Rahbarghazi, Reza
Reiter, Russel J.
An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title_full An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title_fullStr An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title_full_unstemmed An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title_short An Examination of the Putative Role of Melatonin in Exosome Biogenesis
title_sort examination of the putative role of melatonin in exosome biogenesis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219171/
https://www.ncbi.nlm.nih.gov/pubmed/34169078
http://dx.doi.org/10.3389/fcell.2021.686551
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