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Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature

Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotempor...

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Autores principales: Cuenca-Barrales, Carlos, Ruiz-Villaverde, Ricardo, Molina-Leyva, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219322/
https://www.ncbi.nlm.nih.gov/pubmed/34221484
http://dx.doi.org/10.18295/squmj.2021.21.02.025
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author Cuenca-Barrales, Carlos
Ruiz-Villaverde, Ricardo
Molina-Leyva, Alejandro
author_facet Cuenca-Barrales, Carlos
Ruiz-Villaverde, Ricardo
Molina-Leyva, Alejandro
author_sort Cuenca-Barrales, Carlos
collection PubMed
description Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotemporal hairline recession and eyebrow loss. Following trichoscopic examination, the three sisters were diagnosed with FFA. Only one of the sisters agreed to be treated; she was prescribed with topical clobetasol propionate solution and minoxidil and achieved disease control at the three-month follow-up. These patients represent a new case of familial FFA wherein three sisters as well as their mother were affected by FFA. A systematic review found a total of 24 cases of familial FFA, of which this report is the 25th. In the majority of families, only females were affected (88%) while in the remainder both males and females (8%) were affected; there was only one family where only males were affected (4%). The relationship between the affected individuals was predominately between sisters (56%) followed by mother and daughter (32%). The median age was 61 years old (range: 14–88 years) and the duration of the disease ranged between 3–360 months. Family groups of FFA are an infrequently described phenomenon with unknown prevalence.
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spelling pubmed-82193222021-07-02 Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature Cuenca-Barrales, Carlos Ruiz-Villaverde, Ricardo Molina-Leyva, Alejandro Sultan Qaboos Univ Med J Case Report Frontal fibrosing alopecia (FFA) is an emerging disease in Western countries. We present the cases of three sisters who were referred simultaneously to the Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain, in 2018. All patients suffered from at least partial frontotemporal hairline recession and eyebrow loss. Following trichoscopic examination, the three sisters were diagnosed with FFA. Only one of the sisters agreed to be treated; she was prescribed with topical clobetasol propionate solution and minoxidil and achieved disease control at the three-month follow-up. These patients represent a new case of familial FFA wherein three sisters as well as their mother were affected by FFA. A systematic review found a total of 24 cases of familial FFA, of which this report is the 25th. In the majority of families, only females were affected (88%) while in the remainder both males and females (8%) were affected; there was only one family where only males were affected (4%). The relationship between the affected individuals was predominately between sisters (56%) followed by mother and daughter (32%). The median age was 61 years old (range: 14–88 years) and the duration of the disease ranged between 3–360 months. Family groups of FFA are an infrequently described phenomenon with unknown prevalence. Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2021-05 2021-06-21 /pmc/articles/PMC8219322/ /pubmed/34221484 http://dx.doi.org/10.18295/squmj.2021.21.02.025 Text en © Copyright 2021, Sultan Qaboos University Medical Journal, All Rights Reserved https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Case Report
Cuenca-Barrales, Carlos
Ruiz-Villaverde, Ricardo
Molina-Leyva, Alejandro
Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title_full Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title_fullStr Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title_full_unstemmed Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title_short Familial Frontal Fibrosing Alopecia: Report of a case and systematic review of the literature
title_sort familial frontal fibrosing alopecia: report of a case and systematic review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219322/
https://www.ncbi.nlm.nih.gov/pubmed/34221484
http://dx.doi.org/10.18295/squmj.2021.21.02.025
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