Therapeutic delivery of siRNA with polymeric carriers to down-regulate STAT5A expression in high-risk B-cell acute lymphoblastic leukemia (B-ALL)

Overexpression and persistent activation of STAT5 play an important role in the development and progression of acute lymphoblastic leukemia (ALL), the most common pediatric cancer. Small interfering RNA (siRNA)-mediated downregulation of STAT5 represents a promising therapeutic approach for ALL to o...

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Detalles Bibliográficos
Autores principales: Mohseni, Mahsa, Kucharski, Cezary, K. C., Remant Bahadur, Nasrullah, Mohammad, Jiang, Xiaoyan, Uludağ, Hasan, Brandwein, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219370/
https://www.ncbi.nlm.nih.gov/pubmed/34157051
http://dx.doi.org/10.1371/journal.pone.0251719

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