First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization...

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Autores principales: da Costa, Vivaldo Gomes, Saivish, Marielena Vogel, de Oliveira, Priscila Gomes, Silva-Júnior, Abelardo, Moreli, Marcos Lázaro, Krüger, Ricardo Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219677/
https://www.ncbi.nlm.nih.gov/pubmed/34158515
http://dx.doi.org/10.1038/s41598-021-92183-2
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author da Costa, Vivaldo Gomes
Saivish, Marielena Vogel
de Oliveira, Priscila Gomes
Silva-Júnior, Abelardo
Moreli, Marcos Lázaro
Krüger, Ricardo Henrique
author_facet da Costa, Vivaldo Gomes
Saivish, Marielena Vogel
de Oliveira, Priscila Gomes
Silva-Júnior, Abelardo
Moreli, Marcos Lázaro
Krüger, Ricardo Henrique
author_sort da Costa, Vivaldo Gomes
collection PubMed
description The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.
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spelling pubmed-82196772021-06-24 First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil da Costa, Vivaldo Gomes Saivish, Marielena Vogel de Oliveira, Priscila Gomes Silva-Júnior, Abelardo Moreli, Marcos Lázaro Krüger, Ricardo Henrique Sci Rep Article The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil. Nature Publishing Group UK 2021-06-22 /pmc/articles/PMC8219677/ /pubmed/34158515 http://dx.doi.org/10.1038/s41598-021-92183-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
da Costa, Vivaldo Gomes
Saivish, Marielena Vogel
de Oliveira, Priscila Gomes
Silva-Júnior, Abelardo
Moreli, Marcos Lázaro
Krüger, Ricardo Henrique
First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_full First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_fullStr First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_full_unstemmed First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_short First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_sort first complete genome sequence and molecular characterization of canine morbillivirus isolated in central brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219677/
https://www.ncbi.nlm.nih.gov/pubmed/34158515
http://dx.doi.org/10.1038/s41598-021-92183-2
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