Cargando…

Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit

Several clinical calculators predict intensive care unit (ICU) mortality, however these are cumbersome and often require 24 h of data to calculate. Retrospective studies have demonstrated the utility of whole blood transcriptomic analysis in predicting mortality. In this study, we tested prospective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moore, Andrew R., Roque, Jonasel, Shaller, Brian T., Asuni, Tola, Remmel, Melissa, Rawling, David, Liesenfeld, Oliver, Khatri, Purvesh, Wilson, Jennifer G., Levitt, Joseph E., Sweeney, Timothy E., Rogers, Angela J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219678/ https://www.ncbi.nlm.nih.gov/pubmed/34158514 http://dx.doi.org/10.1038/s41598-021-91201-7

Ejemplares similares

A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections
por: Mayhew, Michael B., et al.
Publicado: (2020)

649. Prospective Validation of an 11-mRNA Host Immune Signature as a Novel Blood Test for Acute Septic Arthritis
por: Schultz, Blake, et al.
Publicado: (2019)

2016. TaqMan Multiplex PCR of a Seven-Gene Host Biomarker to Discriminate Bacterial from Viral Infections
por: Nie, Wensheng, et al.
Publicado: (2018)

2021. An Ultra-Rapid Host Response Assay to Discriminate Between Bacterial and Viral Infections Using Quantitative Isothermal Gene Expression Analysis
por: Rawling, David, et al.
Publicado: (2018)

Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis
por: Schultz, Blake J, et al.
Publicado: (2019)

630. A 5-mRNA host response whole-blood classifier trained using patients with non-COVID-19 viral infections accurately predicts severity of COVID-19
por: Buturovic, ljubomir, et al.
Publicado: (2020)

A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections
por: Buturovic, Ljubomir, et al.
Publicado: (2022)

A Multi-mRNA Prognostic Signature for Anti-TNFα Therapy Response in Patients with Inflammatory Bowel Disease
por: Sakaram, Suraj, et al.
Publicado: (2021)

Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections
por: Thair, Simone A., et al.
Publicado: (2020)

521. Similarities and Differences in Transcriptomic Host Response between SARS-CoV-2 and Other Viral Infections
por: Thair, Simone A, et al.
Publicado: (2020)

Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis
por: Wilson, Jennifer G., et al.
Publicado: (2020)

A machine learning classifier using 33 host immune response mRNAs accurately distinguishes viral and non-viral acute respiratory illnesses in nasal swab samples
por: Pandya, Rushika, et al.
Publicado: (2023)

The Optimization and Biological Significance of a 29-Host-Immune-mRNA Panel for the Diagnosis of Acute Infections and Sepsis
por: He, Yudong D., et al.
Publicado: (2021)

Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome
por: Sweeney, Timothy E., et al.
Publicado: (2018)

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
por: Napier, Brooke A., et al.
Publicado: (2016)

Methods to increase reproducibility in differential gene expression via meta-analysis
por: Sweeney, Timothy E., et al.
Publicado: (2017)

A robust gene expression signature for NASH in liver expression data
por: Hasin-Brumshtein, Yehudit, et al.
Publicado: (2022)

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
por: Warsinske, Hayley, et al.
Publicado: (2019)

Cost Impact Model of a Novel Multi-mRNA Host Response Assay for Diagnosis and Risk Assessment of Acute Respiratory Tract Infections and Sepsis in the Emergency Department
por: Schneider, John E., et al.
Publicado: (2020)

Of Screening, Stratification, and Scores
por: Knoppers, Bartha M., et al.
Publicado: (2021)

A Multi-mRNA Host-Response Molecular Blood Test for the Diagnosis and Prognosis of Acute Infections and Sepsis: Proceedings from a Clinical Advisory Panel
por: Ducharme, James, et al.
Publicado: (2020)

Early life immunity in the era of systems biology: understanding development and disease
por: Schaffert, Steven, et al.
Publicado: (2018)

Data Heterogeneity: The Enzyme to Catalyze Translational Bioinformatics?
por: Cahan, Eli M, et al.
Publicado: (2020)

Developing and Applying the Propensity Score to Make Causal Inferences: Variable Selection and Stratification
por: Adelson, Jill L., et al.
Publicado: (2017)

Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses
por: Andres-Terre, Marta, et al.
Publicado: (2015)

Increasing reproducibility, robustness, and generalizability of biomarker selection from meta-analysis using Bayesian methodology
por: Kalesinskas, Laurynas, et al.
Publicado: (2022)

Single-cell RNA-seq methods to interrogate virus-host interactions
por: Ratnasiri, Kalani, et al.
Publicado: (2022)

A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients
por: Safarika, Asimina, et al.
Publicado: (2021)

Our Duty in Relation to Alcohol
por: Shaller, John M.
Publicado: (1910)

MELD-score for risk stratification in cardiac surgery
por: Pathare, Presheet, et al.
Publicado: (2023)

Comparison of three risk stratification scores in gastroschisis neonates: gastroschisis prognostic score, gastroschisis risk stratification index and complex gastroschisis
por: Tauriainen, Asta, et al.
Publicado: (2022)

Risk Stratification and Clinical Utility of Polygenic Risk Scores in Ophthalmology
por: Qassim, Ayub, et al.
Publicado: (2021)

Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
por: Warsinske, Hayley C., et al.
Publicado: (2018)

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
por: Khatri, Purvesh, et al.
Publicado: (2012)

Gene annotation bias impedes biomedical research
por: Haynes, Winston A., et al.
Publicado: (2018)

Cardiac risk stratification: Role of the coronary calcium score
por: Sharma, Rakesh K, et al.
Publicado: (2010)

Demographic history mediates the effect of stratification on polygenic scores
por: Zaidi, Arslan A, et al.
Publicado: (2020)

Host protease activity classifies pneumonia etiology
por: Anahtar, Melodi, et al.
Publicado: (2022)

Immune Reconstitution-Based Score for Risk Stratification of Chronic Graft-Versus-Host Disease Patients
por: Serpenti, Fabio, et al.
Publicado: (2021)

Using a 29-mRNA Host Response Classifier To Detect Bacterial Coinfections and Predict Outcomes in COVID-19 Patients Presenting to the Emergency Department
por: Ram-Mohan, Nikhil, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ovpntovhnnjc8g1kqupbmvc4la