Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

Mitragynine (MG) is the most abundant alkaloid component of the psychoactive plant material “kratom”, which according to numerous anecdotal reports shows efficacy in self-medication for pain syndromes, depression, anxiety, and substance use disorders. We have developed a synthetic method for selecti...

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Detalles Bibliográficos
Autores principales: Bhowmik, Srijita, Galeta, Juraj, Havel, Václav, Nelson, Melissa, Faouzi, Abdelfattah, Bechand, Benjamin, Ansonoff, Mike, Fiala, Tomas, Hunkele, Amanda, Kruegel, Andrew C., Pintar, John. E., Majumdar, Susruta, Javitch, Jonathan A., Sames, Dalibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219695/
https://www.ncbi.nlm.nih.gov/pubmed/34158473
http://dx.doi.org/10.1038/s41467-021-23736-2

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