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Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab

Despite the successful use of the humanized monoclonal antibody trastuzumab (Herceptin) in the clinical treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, the frequently occurring drug resistance remains to be overcome. The regulatory mechanisms of trastuzumab...

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Detalles Bibliográficos
Autores principales:	Zheng, Guoxu, Guo, Zhangyan, Li, Weimiao, Xi, Wenjin, Zuo, Baile, Zhang, Rui, Wen, Weihong, Yang, An-Gang, Jia, Lintao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219715/ https://www.ncbi.nlm.nih.gov/pubmed/34158475 http://dx.doi.org/10.1038/s41392-021-00629-w

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