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The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents
Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively co...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219764/ https://www.ncbi.nlm.nih.gov/pubmed/34158575 http://dx.doi.org/10.1038/s41598-021-92463-x |
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author | Bartkowiak, Joanna Spitzer, Ernest Kurmann, Reto Zürcher, Fabian Krähenmann, Peter Garcia-Ruiz, Victoria Mercado, Jorge Ryffel, Christoph Losdat, Sylvain Llerena, Nassip Torres, Pedro Lanz, Jonas Stocker, Martin Ren, Ben Glöckler, Martin Pilgrim, Thomas |
author_facet | Bartkowiak, Joanna Spitzer, Ernest Kurmann, Reto Zürcher, Fabian Krähenmann, Peter Garcia-Ruiz, Victoria Mercado, Jorge Ryffel, Christoph Losdat, Sylvain Llerena, Nassip Torres, Pedro Lanz, Jonas Stocker, Martin Ren, Ben Glöckler, Martin Pilgrim, Thomas |
author_sort | Bartkowiak, Joanna |
collection | PubMed |
description | Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). LVH was based on left ventricular mass index (LVMI) adjusted for age and sex and defined by a z-score of > 2. LV diastolic function was assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E′), early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity (E/E′) ratio, and left atrial volume index (LAVI). Among 1023 children, 681 children (mean age 12.2 ± 3.1 years, 341 male (50.1%)) were available for the present analysis, of which 150 (22.0%) were obese. LVH was found in 21 (14.0%) obese and in 19 (3.6%) non-obese children (p(adjusted) < 0.001). LVMI was greater in obese than that in non-obese children (36.1 ± 8.6 versus 28.7 ± 6.9 g/m(2.7), p < 0.001). The mean mitral E/E′ ratio and LAVI were significantly higher in obese than those in non-obese individuals (E/E′: 5.2 ± 1.1 versus 4.9 ± 0.8, p(adjusted) = 0.043; LAVI 11.0 ± 3.2 versus 9.6 ± 2.9, p(adjusted) = 0.001), whereas E′ and E/A ratio were comparable. Childhood obesity was associated with left ventricular hypertrophy and determinants of diastolic dysfunction. ClinicalTrials.gov Identifier: NCT02353663. |
format | Online Article Text |
id | pubmed-8219764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82197642021-06-24 The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents Bartkowiak, Joanna Spitzer, Ernest Kurmann, Reto Zürcher, Fabian Krähenmann, Peter Garcia-Ruiz, Victoria Mercado, Jorge Ryffel, Christoph Losdat, Sylvain Llerena, Nassip Torres, Pedro Lanz, Jonas Stocker, Martin Ren, Ben Glöckler, Martin Pilgrim, Thomas Sci Rep Article Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). LVH was based on left ventricular mass index (LVMI) adjusted for age and sex and defined by a z-score of > 2. LV diastolic function was assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E′), early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity (E/E′) ratio, and left atrial volume index (LAVI). Among 1023 children, 681 children (mean age 12.2 ± 3.1 years, 341 male (50.1%)) were available for the present analysis, of which 150 (22.0%) were obese. LVH was found in 21 (14.0%) obese and in 19 (3.6%) non-obese children (p(adjusted) < 0.001). LVMI was greater in obese than that in non-obese children (36.1 ± 8.6 versus 28.7 ± 6.9 g/m(2.7), p < 0.001). The mean mitral E/E′ ratio and LAVI were significantly higher in obese than those in non-obese individuals (E/E′: 5.2 ± 1.1 versus 4.9 ± 0.8, p(adjusted) = 0.043; LAVI 11.0 ± 3.2 versus 9.6 ± 2.9, p(adjusted) = 0.001), whereas E′ and E/A ratio were comparable. Childhood obesity was associated with left ventricular hypertrophy and determinants of diastolic dysfunction. ClinicalTrials.gov Identifier: NCT02353663. Nature Publishing Group UK 2021-06-22 /pmc/articles/PMC8219764/ /pubmed/34158575 http://dx.doi.org/10.1038/s41598-021-92463-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bartkowiak, Joanna Spitzer, Ernest Kurmann, Reto Zürcher, Fabian Krähenmann, Peter Garcia-Ruiz, Victoria Mercado, Jorge Ryffel, Christoph Losdat, Sylvain Llerena, Nassip Torres, Pedro Lanz, Jonas Stocker, Martin Ren, Ben Glöckler, Martin Pilgrim, Thomas The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title_full | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title_fullStr | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title_full_unstemmed | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title_short | The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
title_sort | impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219764/ https://www.ncbi.nlm.nih.gov/pubmed/34158575 http://dx.doi.org/10.1038/s41598-021-92463-x |
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