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Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

The eukaryotic chaperonin TRiC/CCT is a large ATP-dependent complex essential for cellular protein folding. Its subunit arrangement into two stacked eight-membered hetero-oligomeric rings is conserved from yeast to man. A recent breakthrough enables production of functional human TRiC (hTRiC) from i...

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Detalles Bibliográficos
Autores principales:	Collier, Miranda P., Moreira, Karen Betancourt, Li, Kathy H., Chen, Yu-Chan, Itzhak, Daniel, Samant, Rahul, Leitner, Alexander, Burlingame, Alma, Frydman, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219831/ https://www.ncbi.nlm.nih.gov/pubmed/34158536 http://dx.doi.org/10.1038/s41598-021-91086-6

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