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Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients

Aggressive behaviors comprise verbal and/or physical aggression directed toward oneself, others, or objects and are highly prevalent among psychiatric patients, especially patients diagnosed with autism spectrum disorder and severe intellectual disabilities. Some of these patients are considered ref...

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Autores principales: Gouveia, Flavia Venetucci, Germann, Jürgen, Devenyi, Gabriel A., Fonoff, Erich T., Morais, Rosa M. C. B., Brentani, Helena, Chakravarty, M. Mallar, Martinez, Raquel C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219880/
https://www.ncbi.nlm.nih.gov/pubmed/34177490
http://dx.doi.org/10.3389/fnhum.2021.653631
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author Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Fonoff, Erich T.
Morais, Rosa M. C. B.
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
author_facet Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Fonoff, Erich T.
Morais, Rosa M. C. B.
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
author_sort Gouveia, Flavia Venetucci
collection PubMed
description Aggressive behaviors comprise verbal and/or physical aggression directed toward oneself, others, or objects and are highly prevalent among psychiatric patients, especially patients diagnosed with autism spectrum disorder and severe intellectual disabilities. Some of these patients are considered refractory to treatment, and functional neurosurgery targeting the amygdala can result in widespread plastic brain changes that might reflect ceasing of some abnormal brain function, offering symptom alleviation. This study investigated cortical thickness changes in refractory aggressive behavior patients that were treated with bilateral amygdala ablation and compared to control patients presenting non-refractory aggressive behavior [three refractory and seven non-refractory patients, all males diagnosed with autism spectrum disorder (ASD) and intellectual disabilities]. The Overt Aggression Scale (OAS) was used to quantify behavior and magnetic resonance imaging was performed to investigate cortical thickness. Before surgery, both groups presented similar total OAS score, however refractory patients presented higher physical aggression against others. After surgery the refractory group showed 88% average reduction of aggressive behavior. Imaging analysis showed that while refractory patients present an overall reduction in cortical thickness compared to non-refractory patients across both timepoints, the local pattern of thickness difference found in areas of the neurocircuitry of aggressive behavior present before surgery is diminished and no longer detected after surgery. These results corroborate the hypotheses on induction of widespread neuronal plasticity following functional neurosurgical procedures resulting in modifications in brain morphology and improvement in behavior. Further studies are necessary to determine the underlying cause of these morphological changes and to better understand and improve treatment options.
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spelling pubmed-82198802021-06-24 Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients Gouveia, Flavia Venetucci Germann, Jürgen Devenyi, Gabriel A. Fonoff, Erich T. Morais, Rosa M. C. B. Brentani, Helena Chakravarty, M. Mallar Martinez, Raquel C. R. Front Hum Neurosci Neuroscience Aggressive behaviors comprise verbal and/or physical aggression directed toward oneself, others, or objects and are highly prevalent among psychiatric patients, especially patients diagnosed with autism spectrum disorder and severe intellectual disabilities. Some of these patients are considered refractory to treatment, and functional neurosurgery targeting the amygdala can result in widespread plastic brain changes that might reflect ceasing of some abnormal brain function, offering symptom alleviation. This study investigated cortical thickness changes in refractory aggressive behavior patients that were treated with bilateral amygdala ablation and compared to control patients presenting non-refractory aggressive behavior [three refractory and seven non-refractory patients, all males diagnosed with autism spectrum disorder (ASD) and intellectual disabilities]. The Overt Aggression Scale (OAS) was used to quantify behavior and magnetic resonance imaging was performed to investigate cortical thickness. Before surgery, both groups presented similar total OAS score, however refractory patients presented higher physical aggression against others. After surgery the refractory group showed 88% average reduction of aggressive behavior. Imaging analysis showed that while refractory patients present an overall reduction in cortical thickness compared to non-refractory patients across both timepoints, the local pattern of thickness difference found in areas of the neurocircuitry of aggressive behavior present before surgery is diminished and no longer detected after surgery. These results corroborate the hypotheses on induction of widespread neuronal plasticity following functional neurosurgical procedures resulting in modifications in brain morphology and improvement in behavior. Further studies are necessary to determine the underlying cause of these morphological changes and to better understand and improve treatment options. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8219880/ /pubmed/34177490 http://dx.doi.org/10.3389/fnhum.2021.653631 Text en Copyright © 2021 Gouveia, Germann, Devenyi, Fonoff, Morais, Brentani, Chakravarty and Martinez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gouveia, Flavia Venetucci
Germann, Jürgen
Devenyi, Gabriel A.
Fonoff, Erich T.
Morais, Rosa M. C. B.
Brentani, Helena
Chakravarty, M. Mallar
Martinez, Raquel C. R.
Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title_full Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title_fullStr Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title_full_unstemmed Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title_short Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
title_sort bilateral amygdala radio-frequency ablation for refractory aggressive behavior alters local cortical thickness to a pattern found in non-refractory patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219880/
https://www.ncbi.nlm.nih.gov/pubmed/34177490
http://dx.doi.org/10.3389/fnhum.2021.653631
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