Protein-oligonucleotide conjugates as model substrates for DNA-protein crosslink repair proteases

Covalent DNA-protein crosslinks (DPCs) have emerged as pervasive sources of genome instability. DPCs are targeted for repair by DNA-dependent proteases of the Wss1/SPRTN family. However, understanding how these enzymes achieve specificity has been hampered by the lack of suitable in vitro model subs...

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Detalles Bibliográficos
Autores principales: Reinking, Hannah K., Stingele, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219891/
https://www.ncbi.nlm.nih.gov/pubmed/34189469
http://dx.doi.org/10.1016/j.xpro.2021.100591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219891/
https://www.ncbi.nlm.nih.gov/pubmed/34189469
http://dx.doi.org/10.1016/j.xpro.2021.100591

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