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Protein-oligonucleotide conjugates as model substrates for DNA-protein crosslink repair proteases
Covalent DNA-protein crosslinks (DPCs) have emerged as pervasive sources of genome instability. DPCs are targeted for repair by DNA-dependent proteases of the Wss1/SPRTN family. However, understanding how these enzymes achieve specificity has been hampered by the lack of suitable in vitro model subs...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219891/ https://www.ncbi.nlm.nih.gov/pubmed/34189469 http://dx.doi.org/10.1016/j.xpro.2021.100591 |