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The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin
The C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Langerin requires a Ca(2+) cofactor, the binding affinity of which is regulated by pH. Thus, Ca(2+) is bound when langerin is on the membrane but released when langerin and its pathogen substr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219899/ https://www.ncbi.nlm.nih.gov/pubmed/33989634 http://dx.doi.org/10.1016/j.jbc.2021.100718 |