Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System

Tumors of the nervous system can be originated from several locations. They mostly have high mortality and morbidity rate. The emergence of resistance to chemotherapeutic agents is a hurdle in the treatment of patients. Long non-coding RNAs (lncRNAs) have been shown to influence the response of glio...

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Autores principales: Ghafouri-Fard, Soudeh, Agabalazadeh, Amin, Abak, Atefe, Shoorei, Hamed, Hassanzadeh Taheri, Mohammad Mehdi, Taheri, Mohammad, Sharifi, Guive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219921/
https://www.ncbi.nlm.nih.gov/pubmed/34178658
http://dx.doi.org/10.3389/fonc.2021.670917
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author Ghafouri-Fard, Soudeh
Agabalazadeh, Amin
Abak, Atefe
Shoorei, Hamed
Hassanzadeh Taheri, Mohammad Mehdi
Taheri, Mohammad
Sharifi, Guive
author_facet Ghafouri-Fard, Soudeh
Agabalazadeh, Amin
Abak, Atefe
Shoorei, Hamed
Hassanzadeh Taheri, Mohammad Mehdi
Taheri, Mohammad
Sharifi, Guive
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Tumors of the nervous system can be originated from several locations. They mostly have high mortality and morbidity rate. The emergence of resistance to chemotherapeutic agents is a hurdle in the treatment of patients. Long non-coding RNAs (lncRNAs) have been shown to influence the response of glioblastoma/glioma and neuroblastoma to chemotherapeutic agents. MALAT1, NEAT1, and H19 are among lncRNAs that affect the response of glioma/glioblastoma to chemotherapy. As well as that, NORAD, SNHG7, and SNHG16 have been shown to be involved in conferring this phenotype in neuroblastoma. Prior identification of expression amounts of certain lncRNAs would help in the better design of therapeutic regimens. In the current manuscript, we summarize the impact of lncRNAs on chemoresistance in glioma/glioblastoma and neuroblastoma.
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spelling pubmed-82199212021-06-24 Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System Ghafouri-Fard, Soudeh Agabalazadeh, Amin Abak, Atefe Shoorei, Hamed Hassanzadeh Taheri, Mohammad Mehdi Taheri, Mohammad Sharifi, Guive Front Oncol Oncology Tumors of the nervous system can be originated from several locations. They mostly have high mortality and morbidity rate. The emergence of resistance to chemotherapeutic agents is a hurdle in the treatment of patients. Long non-coding RNAs (lncRNAs) have been shown to influence the response of glioblastoma/glioma and neuroblastoma to chemotherapeutic agents. MALAT1, NEAT1, and H19 are among lncRNAs that affect the response of glioma/glioblastoma to chemotherapy. As well as that, NORAD, SNHG7, and SNHG16 have been shown to be involved in conferring this phenotype in neuroblastoma. Prior identification of expression amounts of certain lncRNAs would help in the better design of therapeutic regimens. In the current manuscript, we summarize the impact of lncRNAs on chemoresistance in glioma/glioblastoma and neuroblastoma. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8219921/ /pubmed/34178658 http://dx.doi.org/10.3389/fonc.2021.670917 Text en Copyright © 2021 Ghafouri-Fard, Agabalazadeh, Abak, Shoorei, Hassanzadeh Taheri, Taheri and Sharifi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Agabalazadeh, Amin
Abak, Atefe
Shoorei, Hamed
Hassanzadeh Taheri, Mohammad Mehdi
Taheri, Mohammad
Sharifi, Guive
Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title_full Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title_fullStr Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title_full_unstemmed Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title_short Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System
title_sort role of long non-coding rnas in conferring resistance in tumors of the nervous system
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219921/
https://www.ncbi.nlm.nih.gov/pubmed/34178658
http://dx.doi.org/10.3389/fonc.2021.670917
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