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Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder

Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, re...

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Autores principales: Jia, Cuicui, Ou, Yangpan, Chen, Yunhui, Ma, Jidong, Zhan, Chuang, Lv, Dan, Yang, Ru, Shang, Tinghuizi, Sun, Lei, Wang, Yuhua, Zhang, Guangfeng, Sun, Zhenghai, Wang, Wei, Wang, Xiaoping, Guo, Wenbin, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220135/
https://www.ncbi.nlm.nih.gov/pubmed/34177445
http://dx.doi.org/10.3389/fnins.2021.634557
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author Jia, Cuicui
Ou, Yangpan
Chen, Yunhui
Ma, Jidong
Zhan, Chuang
Lv, Dan
Yang, Ru
Shang, Tinghuizi
Sun, Lei
Wang, Yuhua
Zhang, Guangfeng
Sun, Zhenghai
Wang, Wei
Wang, Xiaoping
Guo, Wenbin
Li, Ping
author_facet Jia, Cuicui
Ou, Yangpan
Chen, Yunhui
Ma, Jidong
Zhan, Chuang
Lv, Dan
Yang, Ru
Shang, Tinghuizi
Sun, Lei
Wang, Yuhua
Zhang, Guangfeng
Sun, Zhenghai
Wang, Wei
Wang, Xiaoping
Guo, Wenbin
Li, Ping
author_sort Jia, Cuicui
collection PubMed
description Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale–Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs.
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spelling pubmed-82201352021-06-24 Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder Jia, Cuicui Ou, Yangpan Chen, Yunhui Ma, Jidong Zhan, Chuang Lv, Dan Yang, Ru Shang, Tinghuizi Sun, Lei Wang, Yuhua Zhang, Guangfeng Sun, Zhenghai Wang, Wei Wang, Xiaoping Guo, Wenbin Li, Ping Front Neurosci Neuroscience Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale–Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8220135/ /pubmed/34177445 http://dx.doi.org/10.3389/fnins.2021.634557 Text en Copyright © 2021 Jia, Ou, Chen, Ma, Zhan, Lv, Yang, Shang, Sun, Wang, Zhang, Sun, Wang, Wang, Guo and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jia, Cuicui
Ou, Yangpan
Chen, Yunhui
Ma, Jidong
Zhan, Chuang
Lv, Dan
Yang, Ru
Shang, Tinghuizi
Sun, Lei
Wang, Yuhua
Zhang, Guangfeng
Sun, Zhenghai
Wang, Wei
Wang, Xiaoping
Guo, Wenbin
Li, Ping
Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title_full Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title_fullStr Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title_full_unstemmed Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title_short Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder
title_sort disrupted asymmetry of inter- and intra-hemispheric functional connectivity at rest in medication-free obsessive-compulsive disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220135/
https://www.ncbi.nlm.nih.gov/pubmed/34177445
http://dx.doi.org/10.3389/fnins.2021.634557
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