The Role of CLEC-2 and Its Ligands in Thromboinflammation

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years...

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Detalles Bibliográficos
Autores principales: Meng, Danyang, Luo, Man, Liu, Beibei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220156/
https://www.ncbi.nlm.nih.gov/pubmed/34177942
http://dx.doi.org/10.3389/fimmu.2021.688643
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author Meng, Danyang
Luo, Man
Liu, Beibei
author_facet Meng, Danyang
Luo, Man
Liu, Beibei
author_sort Meng, Danyang
collection PubMed
description C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.
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spelling pubmed-82201562021-06-24 The Role of CLEC-2 and Its Ligands in Thromboinflammation Meng, Danyang Luo, Man Liu, Beibei Front Immunol Immunology C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8220156/ /pubmed/34177942 http://dx.doi.org/10.3389/fimmu.2021.688643 Text en Copyright © 2021 Meng, Luo and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Meng, Danyang
Luo, Man
Liu, Beibei
The Role of CLEC-2 and Its Ligands in Thromboinflammation
title The Role of CLEC-2 and Its Ligands in Thromboinflammation
title_full The Role of CLEC-2 and Its Ligands in Thromboinflammation
title_fullStr The Role of CLEC-2 and Its Ligands in Thromboinflammation
title_full_unstemmed The Role of CLEC-2 and Its Ligands in Thromboinflammation
title_short The Role of CLEC-2 and Its Ligands in Thromboinflammation
title_sort role of clec-2 and its ligands in thromboinflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220156/
https://www.ncbi.nlm.nih.gov/pubmed/34177942
http://dx.doi.org/10.3389/fimmu.2021.688643
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