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Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report
BACKGROUND: Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported. CASE PRESENTATION: We rep...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220165/ https://www.ncbi.nlm.nih.gov/pubmed/34188905 http://dx.doi.org/10.1016/j.amsu.2021.102475 |
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author | Tlili, Ghassen Ammar, Houssem Majdoub, Wiem Dziri, Sonia Farhat, Waad Acacha, Emir Gupta, Rahul Jalleli, Najmeddine Azzabi, Awatef Jaidane, Mehdi |
author_facet | Tlili, Ghassen Ammar, Houssem Majdoub, Wiem Dziri, Sonia Farhat, Waad Acacha, Emir Gupta, Rahul Jalleli, Najmeddine Azzabi, Awatef Jaidane, Mehdi |
author_sort | Tlili, Ghassen |
collection | PubMed |
description | BACKGROUND: Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported. CASE PRESENTATION: We report a case of a 49-year-old man presenting paraplegia caused by a metastatic urinary bladder LCNEC, which was managed with palliative external beam radiotherapy (EBRT) associated with MVAC chemotherapy, including methotrexate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and cisplatin. At the last follow-up of one year after his admission, there was a symptomatic improvement in the pain intensity. CONCLUSION: LCNEC of the bladder was first described in 1986, and, until now, less than 40 cases have been published in the literature. To the best of our knowledge, this is the first case of primary LCNEC of the urinary bladder presenting with paraplegia. |
format | Online Article Text |
id | pubmed-8220165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82201652021-06-28 Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report Tlili, Ghassen Ammar, Houssem Majdoub, Wiem Dziri, Sonia Farhat, Waad Acacha, Emir Gupta, Rahul Jalleli, Najmeddine Azzabi, Awatef Jaidane, Mehdi Ann Med Surg (Lond) Case Report BACKGROUND: Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported. CASE PRESENTATION: We report a case of a 49-year-old man presenting paraplegia caused by a metastatic urinary bladder LCNEC, which was managed with palliative external beam radiotherapy (EBRT) associated with MVAC chemotherapy, including methotrexate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and cisplatin. At the last follow-up of one year after his admission, there was a symptomatic improvement in the pain intensity. CONCLUSION: LCNEC of the bladder was first described in 1986, and, until now, less than 40 cases have been published in the literature. To the best of our knowledge, this is the first case of primary LCNEC of the urinary bladder presenting with paraplegia. Elsevier 2021-06-06 /pmc/articles/PMC8220165/ /pubmed/34188905 http://dx.doi.org/10.1016/j.amsu.2021.102475 Text en © 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Tlili, Ghassen Ammar, Houssem Majdoub, Wiem Dziri, Sonia Farhat, Waad Acacha, Emir Gupta, Rahul Jalleli, Najmeddine Azzabi, Awatef Jaidane, Mehdi Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title | Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title_full | Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title_fullStr | Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title_full_unstemmed | Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title_short | Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report |
title_sort | paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220165/ https://www.ncbi.nlm.nih.gov/pubmed/34188905 http://dx.doi.org/10.1016/j.amsu.2021.102475 |
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