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Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion
Cardiovascular disease (CVD) is the leading cause of death in the global population, accounting for about one-third of all deaths each year. Notably, with CVDs, myocardial damages result from myocardial infarction (MI) or cardiac arrhythmias caused by interrupted blood flow. Significantly, in the pr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220218/ https://www.ncbi.nlm.nih.gov/pubmed/34179002 http://dx.doi.org/10.3389/fcell.2021.673677 |
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author | Wu, Xun Iroegbu, Chukwuemeka Daniel Peng, Jun Guo, Jianjun Yang, Jinfu Fan, Chengming |
author_facet | Wu, Xun Iroegbu, Chukwuemeka Daniel Peng, Jun Guo, Jianjun Yang, Jinfu Fan, Chengming |
author_sort | Wu, Xun |
collection | PubMed |
description | Cardiovascular disease (CVD) is the leading cause of death in the global population, accounting for about one-third of all deaths each year. Notably, with CVDs, myocardial damages result from myocardial infarction (MI) or cardiac arrhythmias caused by interrupted blood flow. Significantly, in the process of MI or myocardial ischemic-reperfusion (I/R) injury, both regulated and non-regulated cell death methods are involved. The critical factor for patients’ prognosis is the infarct area’s size, which determines the myocardial cells’ survival. Cell therapy for MI has been a research hotspot in recent years; however, exosomes secreted by cells have attracted much attention following shortcomings concerning immunogens. Exosomes are extracellular vesicles containing several biologically active substances such as lipids, nucleic acids, and proteins. New evidence suggests that exosomes play a crucial role in regulating cell death after MI as exosomes of various stem cells can participate in the cell damage process after MI. Hence, in the review herein, we focused on introducing various cell-derived exosomes to reduce cell death after MI by regulating the cell death pathway to understand myocardial repair mechanisms better and provide a reference for clinical treatment. |
format | Online Article Text |
id | pubmed-8220218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82202182021-06-24 Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion Wu, Xun Iroegbu, Chukwuemeka Daniel Peng, Jun Guo, Jianjun Yang, Jinfu Fan, Chengming Front Cell Dev Biol Cell and Developmental Biology Cardiovascular disease (CVD) is the leading cause of death in the global population, accounting for about one-third of all deaths each year. Notably, with CVDs, myocardial damages result from myocardial infarction (MI) or cardiac arrhythmias caused by interrupted blood flow. Significantly, in the process of MI or myocardial ischemic-reperfusion (I/R) injury, both regulated and non-regulated cell death methods are involved. The critical factor for patients’ prognosis is the infarct area’s size, which determines the myocardial cells’ survival. Cell therapy for MI has been a research hotspot in recent years; however, exosomes secreted by cells have attracted much attention following shortcomings concerning immunogens. Exosomes are extracellular vesicles containing several biologically active substances such as lipids, nucleic acids, and proteins. New evidence suggests that exosomes play a crucial role in regulating cell death after MI as exosomes of various stem cells can participate in the cell damage process after MI. Hence, in the review herein, we focused on introducing various cell-derived exosomes to reduce cell death after MI by regulating the cell death pathway to understand myocardial repair mechanisms better and provide a reference for clinical treatment. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8220218/ /pubmed/34179002 http://dx.doi.org/10.3389/fcell.2021.673677 Text en Copyright © 2021 Wu, Iroegbu, Peng, Guo, Yang and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wu, Xun Iroegbu, Chukwuemeka Daniel Peng, Jun Guo, Jianjun Yang, Jinfu Fan, Chengming Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title | Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title_full | Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title_fullStr | Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title_full_unstemmed | Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title_short | Cell Death and Exosomes Regulation After Myocardial Infarction and Ischemia-Reperfusion |
title_sort | cell death and exosomes regulation after myocardial infarction and ischemia-reperfusion |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220218/ https://www.ncbi.nlm.nih.gov/pubmed/34179002 http://dx.doi.org/10.3389/fcell.2021.673677 |
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