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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria complex I oxygen consumption, Akt-FOXO signaling, blocked cell cy...
Autores principales: | AbuEid, Mahmoud, McAllister, Donna M., McOlash, Laura, Harwig, Megan Cleland, Cheng, Gang, Drouillard, Donovan, Boyle, Kathleen A., Hardy, Micael, Zielonka, Jacek, Johnson, Bryon D., Hill, R. Blake, Kalyanaraman, Balaraman, Dwinell, Michael B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220235/ https://www.ncbi.nlm.nih.gov/pubmed/34189432 http://dx.doi.org/10.1016/j.isci.2021.102653 |
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