Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules

Incidence of hepatotoxicity following acute drug-induced proteasomal inhibition and development of chronic proteasome dysfunction in obesity and insulin resistance underscores the crucial importance of hepatic protein homeostasis albeit with an elusive molecular basis and therapeutic opportunities....

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Detalles Bibliográficos
Autores principales: Das, Debajyoti, Paul, Avishek, Lahiri, Abhishake, Adak, Moumita, Maity, Sujay K., Sarkar, Ankita, Paul, Sandip, Chakrabarti, Partha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220246/
https://www.ncbi.nlm.nih.gov/pubmed/34144391
http://dx.doi.org/10.1016/j.redox.2021.102043

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