Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

AIMS: Homozygosity for a four‐missense single‐nucleotide polymorphism haplotype of the human BPIFB4 gene is enriched in long‐living individuals. Delivery of this longevity‐associated variant (LAV) improved revascularisation and reduced endothelial dysfunction and atherosclerosis in mice through a me...

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Detalles Bibliográficos
Autores principales: Dang, Zexu, Avolio, Elisa, Thomas, Anita C., Faulkner, Ashton, Beltrami, Antonio P., Cervellin, Celeste, Carrizzo, Albino, Maciag, Anna, Gu, Yue, Ciaglia, Elena, Finato, Nicoletta, Damato, Antonio, Spinetti, Gaia, Alenzi, Aishah, Paisey, Stephen J., Vecchione, Carmine, Puca, Annibale A., Madeddu, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2020
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220375/
https://www.ncbi.nlm.nih.gov/pubmed/32384208
http://dx.doi.org/10.1002/ejhf.1840

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