SARS-CoV-2 late shedding may be infectious between immunocompromised hosts

BACKGROUND: Immunocompromised patients shed SARS-CoV-2 for extended periods, but to our knowledge person-to-person transmission from late shedding has not been reported. THE CASE: We present a case in which a COVID-19 patient infected another over 28 days after the patient’s initial symptoms, past c...

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Autores principales: Kaila, Ville, Sirkeoja, Simo, Blomqvist, Soile, Rannikko, Juha, Viskari, Hanna, Lyly-Yrjänäinen, Tiina, Syrjänen, Jaana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220436/
https://www.ncbi.nlm.nih.gov/pubmed/34137349
http://dx.doi.org/10.1080/23744235.2021.1939891
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author Kaila, Ville
Sirkeoja, Simo
Blomqvist, Soile
Rannikko, Juha
Viskari, Hanna
Lyly-Yrjänäinen, Tiina
Syrjänen, Jaana
author_facet Kaila, Ville
Sirkeoja, Simo
Blomqvist, Soile
Rannikko, Juha
Viskari, Hanna
Lyly-Yrjänäinen, Tiina
Syrjänen, Jaana
author_sort Kaila, Ville
collection PubMed
description BACKGROUND: Immunocompromised patients shed SARS-CoV-2 for extended periods, but to our knowledge person-to-person transmission from late shedding has not been reported. THE CASE: We present a case in which a COVID-19 patient infected another over 28 days after the patient’s initial symptoms, past current guideline recommendations of 20 days for length of isolation in immunocompromised patients. Whole genome sequencing of their viruses was performed to ascertain the transmission. DISCUSSION: Severely immunocompromised patients, whose clearance of the virus is impaired, may remain infectious for extended periods. Caution should be taken particularly in hospital settings where lapses in isolation procedures might pose increased risk, especially to other immunocompromised patients.
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spelling pubmed-82204362021-06-23 SARS-CoV-2 late shedding may be infectious between immunocompromised hosts Kaila, Ville Sirkeoja, Simo Blomqvist, Soile Rannikko, Juha Viskari, Hanna Lyly-Yrjänäinen, Tiina Syrjänen, Jaana Infect Dis (Lond) Case Report BACKGROUND: Immunocompromised patients shed SARS-CoV-2 for extended periods, but to our knowledge person-to-person transmission from late shedding has not been reported. THE CASE: We present a case in which a COVID-19 patient infected another over 28 days after the patient’s initial symptoms, past current guideline recommendations of 20 days for length of isolation in immunocompromised patients. Whole genome sequencing of their viruses was performed to ascertain the transmission. DISCUSSION: Severely immunocompromised patients, whose clearance of the virus is impaired, may remain infectious for extended periods. Caution should be taken particularly in hospital settings where lapses in isolation procedures might pose increased risk, especially to other immunocompromised patients. Taylor & Francis 2021-06-17 /pmc/articles/PMC8220436/ /pubmed/34137349 http://dx.doi.org/10.1080/23744235.2021.1939891 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Case Report
Kaila, Ville
Sirkeoja, Simo
Blomqvist, Soile
Rannikko, Juha
Viskari, Hanna
Lyly-Yrjänäinen, Tiina
Syrjänen, Jaana
SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title_full SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title_fullStr SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title_full_unstemmed SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title_short SARS-CoV-2 late shedding may be infectious between immunocompromised hosts
title_sort sars-cov-2 late shedding may be infectious between immunocompromised hosts
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220436/
https://www.ncbi.nlm.nih.gov/pubmed/34137349
http://dx.doi.org/10.1080/23744235.2021.1939891
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