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Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220452/ https://www.ncbi.nlm.nih.gov/pubmed/34158320 http://dx.doi.org/10.1136/bcr-2020-236436 |
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author | Mohd Ramli, Siti Sarah Husain, Salina Wong, Yin Ping |
author_facet | Mohd Ramli, Siti Sarah Husain, Salina Wong, Yin Ping |
author_sort | Mohd Ramli, Siti Sarah |
collection | PubMed |
description | A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type. In-situ hybridisation for Epstein-Barr encoding region was positive. He was treated with six cycles of gemcitabine, oxaliplatin and L-asparaginase and peripheral blood stem cell transplant. After the treatment, he was asymptomatic until 9 months where he had splenic abscess and undergone splenectomy. He was asymptomatic of the disease for 2 years. |
format | Online Article Text |
id | pubmed-8220452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-82204522021-07-09 Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation Mohd Ramli, Siti Sarah Husain, Salina Wong, Yin Ping BMJ Case Rep Case Report A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type. In-situ hybridisation for Epstein-Barr encoding region was positive. He was treated with six cycles of gemcitabine, oxaliplatin and L-asparaginase and peripheral blood stem cell transplant. After the treatment, he was asymptomatic until 9 months where he had splenic abscess and undergone splenectomy. He was asymptomatic of the disease for 2 years. BMJ Publishing Group 2021-06-22 /pmc/articles/PMC8220452/ /pubmed/34158320 http://dx.doi.org/10.1136/bcr-2020-236436 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Report Mohd Ramli, Siti Sarah Husain, Salina Wong, Yin Ping Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title | Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title_full | Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title_fullStr | Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title_full_unstemmed | Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title_short | Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
title_sort | extranodal nk/t cell lymphoma, nasal type: a rare diagnosis with common nasal presentation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220452/ https://www.ncbi.nlm.nih.gov/pubmed/34158320 http://dx.doi.org/10.1136/bcr-2020-236436 |
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