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Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation

A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type....

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Detalles Bibliográficos
Autores principales: Mohd Ramli, Siti Sarah, Husain, Salina, Wong, Yin Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220452/
https://www.ncbi.nlm.nih.gov/pubmed/34158320
http://dx.doi.org/10.1136/bcr-2020-236436
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author Mohd Ramli, Siti Sarah
Husain, Salina
Wong, Yin Ping
author_facet Mohd Ramli, Siti Sarah
Husain, Salina
Wong, Yin Ping
author_sort Mohd Ramli, Siti Sarah
collection PubMed
description A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type. In-situ hybridisation for Epstein-Barr encoding region was positive. He was treated with six cycles of gemcitabine, oxaliplatin and L-asparaginase and peripheral blood stem cell transplant. After the treatment, he was asymptomatic until 9 months where he had splenic abscess and undergone splenectomy. He was asymptomatic of the disease for 2 years.
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spelling pubmed-82204522021-07-09 Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation Mohd Ramli, Siti Sarah Husain, Salina Wong, Yin Ping BMJ Case Rep Case Report A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type. In-situ hybridisation for Epstein-Barr encoding region was positive. He was treated with six cycles of gemcitabine, oxaliplatin and L-asparaginase and peripheral blood stem cell transplant. After the treatment, he was asymptomatic until 9 months where he had splenic abscess and undergone splenectomy. He was asymptomatic of the disease for 2 years. BMJ Publishing Group 2021-06-22 /pmc/articles/PMC8220452/ /pubmed/34158320 http://dx.doi.org/10.1136/bcr-2020-236436 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Mohd Ramli, Siti Sarah
Husain, Salina
Wong, Yin Ping
Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title_full Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title_fullStr Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title_full_unstemmed Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title_short Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
title_sort extranodal nk/t cell lymphoma, nasal type: a rare diagnosis with common nasal presentation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220452/
https://www.ncbi.nlm.nih.gov/pubmed/34158320
http://dx.doi.org/10.1136/bcr-2020-236436
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