Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes

[Image: see text] Inspired by the proposed inner-sphere mechanism of the tungstoenzyme acetylene hydratase, we have designed tungsten acetylene complexes and investigated their reactivity. Here, we report the first intermolecular nucleophilic attack on a tungsten-bound acetylene (C(2)H(2)) in bioins...

Descripción completa

Detalles Bibliográficos
Autores principales: Ehweiner, Madeleine A., Peschel, Lydia M., Stix, Niklas, Ćorović, Miljan Z., Belaj, Ferdinand, Mösch-Zanetti, Nadia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220502/
https://www.ncbi.nlm.nih.gov/pubmed/33852290
http://dx.doi.org/10.1021/acs.inorgchem.1c00643
_version_ 1783711160314363904
author Ehweiner, Madeleine A.
Peschel, Lydia M.
Stix, Niklas
Ćorović, Miljan Z.
Belaj, Ferdinand
Mösch-Zanetti, Nadia C.
author_facet Ehweiner, Madeleine A.
Peschel, Lydia M.
Stix, Niklas
Ćorović, Miljan Z.
Belaj, Ferdinand
Mösch-Zanetti, Nadia C.
author_sort Ehweiner, Madeleine A.
collection PubMed
description [Image: see text] Inspired by the proposed inner-sphere mechanism of the tungstoenzyme acetylene hydratase, we have designed tungsten acetylene complexes and investigated their reactivity. Here, we report the first intermolecular nucleophilic attack on a tungsten-bound acetylene (C(2)H(2)) in bioinspired complexes employing 6-methylpyridine-2-thiolate ligands. By using PMe(3) as a nucleophile, we isolated cationic carbyne and alkenyl complexes.
format Online
Article
Text
id pubmed-8220502
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-82205022021-06-24 Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes Ehweiner, Madeleine A. Peschel, Lydia M. Stix, Niklas Ćorović, Miljan Z. Belaj, Ferdinand Mösch-Zanetti, Nadia C. Inorg Chem [Image: see text] Inspired by the proposed inner-sphere mechanism of the tungstoenzyme acetylene hydratase, we have designed tungsten acetylene complexes and investigated their reactivity. Here, we report the first intermolecular nucleophilic attack on a tungsten-bound acetylene (C(2)H(2)) in bioinspired complexes employing 6-methylpyridine-2-thiolate ligands. By using PMe(3) as a nucleophile, we isolated cationic carbyne and alkenyl complexes. American Chemical Society 2021-04-14 2021-06-21 /pmc/articles/PMC8220502/ /pubmed/33852290 http://dx.doi.org/10.1021/acs.inorgchem.1c00643 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Ehweiner, Madeleine A.
Peschel, Lydia M.
Stix, Niklas
Ćorović, Miljan Z.
Belaj, Ferdinand
Mösch-Zanetti, Nadia C.
Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title_full Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title_fullStr Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title_full_unstemmed Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title_short Bioinspired Nucleophilic Attack on a Tungsten-Bound Acetylene: Formation of Cationic Carbyne and Alkenyl Complexes
title_sort bioinspired nucleophilic attack on a tungsten-bound acetylene: formation of cationic carbyne and alkenyl complexes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220502/
https://www.ncbi.nlm.nih.gov/pubmed/33852290
http://dx.doi.org/10.1021/acs.inorgchem.1c00643
work_keys_str_mv AT ehweinermadeleinea bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes
AT peschellydiam bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes
AT stixniklas bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes
AT corovicmiljanz bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes
AT belajferdinand bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes
AT moschzanettinadiac bioinspirednucleophilicattackonatungstenboundacetyleneformationofcationiccarbyneandalkenylcomplexes

Ejemplares similares