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Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and frequently diagnosed malignant tumor of the pancreas with few treatment options and poor life expectancy. Despite the advances in the surgical field, 40% of the patients are diagnosed with locally advanced disease which is not sui...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220652/ https://www.ncbi.nlm.nih.gov/pubmed/34178126 http://dx.doi.org/10.3892/etm.2021.10285 |
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author | Iancu, Ioana Bartoș, Adrian Cioltean, Cristian Liviu Breazu, Caius Iancu, Cornel Bartoș, Dana |
author_facet | Iancu, Ioana Bartoș, Adrian Cioltean, Cristian Liviu Breazu, Caius Iancu, Cornel Bartoș, Dana |
author_sort | Iancu, Ioana |
collection | PubMed |
description | Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and frequently diagnosed malignant tumor of the pancreas with few treatment options and poor life expectancy. Despite the advances in the surgical field, 40% of the patients are diagnosed with locally advanced disease which is not suitable for surgery. Radio-frequency ablation (RFA) has been described as a new ‘weapon’ in the multimodal treatment of PDAC, representing a cytoreductive procedure which must be completed with radiotherapy or chemo-radiotherapy. A systematic research was carried out utilizing the PubMed database in regards to this subject, to evaluate the role of RFA in PDAC management. Abstracts, letters-to-the-editor and non-English language manuscripts were excluded. The literature showed that RFA can be used in open and laparoscopic surgery but it is also feasible for endoscopic ultrasound (EUS-guided RFA) or percutaneous approach. Even though we found optimistic and encouraging reports on overall survival (OS), randomized studies are still required to corroborate these findings. Our review research underline that surgical resection remains the only radical treatment option, RFA being a safe and feasible technique reserved for unresectable, non-metastatic pancreatic tumors. Its combination with oncological treatment can improve the OS of these patients. |
format | Online Article Text |
id | pubmed-8220652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-82206522021-06-26 Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) Iancu, Ioana Bartoș, Adrian Cioltean, Cristian Liviu Breazu, Caius Iancu, Cornel Bartoș, Dana Exp Ther Med Review Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and frequently diagnosed malignant tumor of the pancreas with few treatment options and poor life expectancy. Despite the advances in the surgical field, 40% of the patients are diagnosed with locally advanced disease which is not suitable for surgery. Radio-frequency ablation (RFA) has been described as a new ‘weapon’ in the multimodal treatment of PDAC, representing a cytoreductive procedure which must be completed with radiotherapy or chemo-radiotherapy. A systematic research was carried out utilizing the PubMed database in regards to this subject, to evaluate the role of RFA in PDAC management. Abstracts, letters-to-the-editor and non-English language manuscripts were excluded. The literature showed that RFA can be used in open and laparoscopic surgery but it is also feasible for endoscopic ultrasound (EUS-guided RFA) or percutaneous approach. Even though we found optimistic and encouraging reports on overall survival (OS), randomized studies are still required to corroborate these findings. Our review research underline that surgical resection remains the only radical treatment option, RFA being a safe and feasible technique reserved for unresectable, non-metastatic pancreatic tumors. Its combination with oncological treatment can improve the OS of these patients. D.A. Spandidos 2021-08 2021-06-08 /pmc/articles/PMC8220652/ /pubmed/34178126 http://dx.doi.org/10.3892/etm.2021.10285 Text en Copyright: © Iancu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Iancu, Ioana Bartoș, Adrian Cioltean, Cristian Liviu Breazu, Caius Iancu, Cornel Bartoș, Dana Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title | Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title_full | Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title_fullStr | Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title_full_unstemmed | Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title_short | Role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review) |
title_sort | role of radio-ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220652/ https://www.ncbi.nlm.nih.gov/pubmed/34178126 http://dx.doi.org/10.3892/etm.2021.10285 |
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