Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers

Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer cell lines and regulate cell signaling pathways by modulatin...

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Autores principales: Garlapati, Pranavi, Ling, Jinjie, Chiao, Paul J., Fu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220689/
https://www.ncbi.nlm.nih.gov/pubmed/34162394
http://dx.doi.org/10.1186/s12935-021-02017-4
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author Garlapati, Pranavi
Ling, Jinjie
Chiao, Paul J.
Fu, Jie
author_facet Garlapati, Pranavi
Ling, Jinjie
Chiao, Paul J.
Fu, Jie
author_sort Garlapati, Pranavi
collection PubMed
description Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer cell lines and regulate cell signaling pathways by modulating particular gene expressions. Understanding their role in these pathways and what cancers they are found in can set the stage for identifying diagnostic and prognostic biomarkers and therapeutic targets of cancer. This paper will discuss which circRNAs are found in different cancers and what mechanisms they use to upregulate or downregulate certain cellular components.
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spelling pubmed-82206892021-06-23 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers Garlapati, Pranavi Ling, Jinjie Chiao, Paul J. Fu, Jie Cancer Cell Int Review Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differentially expressed in various cancer cell lines and regulate cell signaling pathways by modulating particular gene expressions. Understanding their role in these pathways and what cancers they are found in can set the stage for identifying diagnostic and prognostic biomarkers and therapeutic targets of cancer. This paper will discuss which circRNAs are found in different cancers and what mechanisms they use to upregulate or downregulate certain cellular components. BioMed Central 2021-06-23 /pmc/articles/PMC8220689/ /pubmed/34162394 http://dx.doi.org/10.1186/s12935-021-02017-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Garlapati, Pranavi
Ling, Jinjie
Chiao, Paul J.
Fu, Jie
Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title_full Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title_fullStr Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title_full_unstemmed Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title_short Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
title_sort circular rnas regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220689/
https://www.ncbi.nlm.nih.gov/pubmed/34162394
http://dx.doi.org/10.1186/s12935-021-02017-4
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