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Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice

The deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that cause the spreading of template-directed aggregation of specific disease-associated proteins. I...

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Detalles Bibliográficos
Autores principales:	Keskin, Isil, Ekhtiari Bidhendi, Elaheh, Marklund, Matthew, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Nordström, Ulrika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220797/ https://www.ncbi.nlm.nih.gov/pubmed/34158126 http://dx.doi.org/10.1186/s40478-021-01211-9

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