α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na(+) Reabsorption During High Glucose Conditions

Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na(+) handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin to promote angiotensin (Ang) II formation, thereby contrib...

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Detalles Bibliográficos
Autores principales: Guerrero, Aarón, Visniauskas, Bruna, Cárdenas, Pilar, Figueroa, Stefanny M., Vivanco, Jorge, Salinas-Parra, Nicolas, Araos, Patricio, Nguyen, Quynh My, Kassan, Modar, Amador, Cristián A., Prieto, Minolfa C., Gonzalez, Alexis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220822/
https://www.ncbi.nlm.nih.gov/pubmed/34179130
http://dx.doi.org/10.3389/fcvm.2021.644797

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