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The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial

BACKGROUND: Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH). In humans, acute continuous hypoxia slightly increases plasma triglycerides...

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Autores principales: Morin, Renée, Mauger, Jean-François, Amaratunga, Ruwan, Imbeault, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220832/
https://www.ncbi.nlm.nih.gov/pubmed/34158069
http://dx.doi.org/10.1186/s12967-021-02933-z
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author Morin, Renée
Mauger, Jean-François
Amaratunga, Ruwan
Imbeault, Pascal
author_facet Morin, Renée
Mauger, Jean-François
Amaratunga, Ruwan
Imbeault, Pascal
author_sort Morin, Renée
collection PubMed
description BACKGROUND: Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH). In humans, acute continuous hypoxia slightly increases plasma triglycerides (TG). However, no study yet compared the postprandial TG response of individuals with or without OSA under intermittent hypoxia. METHODS: Using a randomized crossover design, seven individuals diagnosed with moderate OSA and eight healthy individuals without OSA were given a meal after which they were exposed for 6 h to normoxia or intermittent hypoxia (e.g., 15 hypoxic events per hour). Blood lipid levels were measured hourly during each session. RESULTS: Peak postprandial TG concentrations tended to be 22% higher under IH irrespective of group (IH × time interaction, p = 0.068). This trend toward higher total plasma TG was attributable to increased levels of denser TG-rich lipoproteins such as very low-density lipoproteins (VLDL) and chylomicrons (CM) remnants. Irrespective of group, the postprandial TG concentrations in denser TG-rich lipoproteins was 20% higher under IH (IH × time interaction, p = 0.036), although IH had virtually no impact on denser TG-rich lipoprotein concentrations in the OSA group. CONCLUSION: Acute intermittent hypoxia tends to negatively affect postprandial TG levels in healthy individuals, which is attributable to an increase in denser TG-carrying lipoprotein levels such as VLDL and CM remnants. This altered postprandial TG response to acute intermittent hypoxia was not observed in individuals with OSA.
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spelling pubmed-82208322021-06-24 The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial Morin, Renée Mauger, Jean-François Amaratunga, Ruwan Imbeault, Pascal J Transl Med Research BACKGROUND: Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH). In humans, acute continuous hypoxia slightly increases plasma triglycerides (TG). However, no study yet compared the postprandial TG response of individuals with or without OSA under intermittent hypoxia. METHODS: Using a randomized crossover design, seven individuals diagnosed with moderate OSA and eight healthy individuals without OSA were given a meal after which they were exposed for 6 h to normoxia or intermittent hypoxia (e.g., 15 hypoxic events per hour). Blood lipid levels were measured hourly during each session. RESULTS: Peak postprandial TG concentrations tended to be 22% higher under IH irrespective of group (IH × time interaction, p = 0.068). This trend toward higher total plasma TG was attributable to increased levels of denser TG-rich lipoproteins such as very low-density lipoproteins (VLDL) and chylomicrons (CM) remnants. Irrespective of group, the postprandial TG concentrations in denser TG-rich lipoproteins was 20% higher under IH (IH × time interaction, p = 0.036), although IH had virtually no impact on denser TG-rich lipoprotein concentrations in the OSA group. CONCLUSION: Acute intermittent hypoxia tends to negatively affect postprandial TG levels in healthy individuals, which is attributable to an increase in denser TG-carrying lipoprotein levels such as VLDL and CM remnants. This altered postprandial TG response to acute intermittent hypoxia was not observed in individuals with OSA. BioMed Central 2021-06-22 /pmc/articles/PMC8220832/ /pubmed/34158069 http://dx.doi.org/10.1186/s12967-021-02933-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Morin, Renée
Mauger, Jean-François
Amaratunga, Ruwan
Imbeault, Pascal
The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title_full The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title_fullStr The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title_full_unstemmed The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title_short The effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
title_sort effect of acute intermittent hypoxia on postprandial triglyceride levels in humans: a randomized crossover trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220832/
https://www.ncbi.nlm.nih.gov/pubmed/34158069
http://dx.doi.org/10.1186/s12967-021-02933-z
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