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Sex-Related Differences in the Effects of Sports-Related Concussion: A Review
Sports-related concussion is a serious health challenge, and females are at higher risk of sustaining a sports-related concussion compared to males. Although there are many studies that investigate outcomes following concussion, females remain an understudied population, despite representing a large...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221087/ https://www.ncbi.nlm.nih.gov/pubmed/32533752 http://dx.doi.org/10.1111/jon.12726 |
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author | Koerte, Inga K. Schultz, Vivian Sydnor, Valerie J. Howell, David R. Guenette, Jeffrey P. Dennis, Emily Kochsiek, Janna Kaufmann, David Sollmann, Nico Mondello, Stefania Shenton, Martha E. Lin, Alexander P. |
author_facet | Koerte, Inga K. Schultz, Vivian Sydnor, Valerie J. Howell, David R. Guenette, Jeffrey P. Dennis, Emily Kochsiek, Janna Kaufmann, David Sollmann, Nico Mondello, Stefania Shenton, Martha E. Lin, Alexander P. |
author_sort | Koerte, Inga K. |
collection | PubMed |
description | Sports-related concussion is a serious health challenge, and females are at higher risk of sustaining a sports-related concussion compared to males. Although there are many studies that investigate outcomes following concussion, females remain an understudied population, despite representing a large proportion of the organized sports community. In this review, we provide a summary of studies that investigate sex-related differences in outcome following sports-related concussion. Moreover, we provide an introduction to the methods used to study sex-related differences after sports-related concussion, including common clinical and cognitive measures, neuroimaging techniques, as well as biomarkers. A literature search inclusive of articles published to March 2020 was performed using PubMed. The studies were reviewed and discussed with regard to the methods used. Findings from these studies remain mixed with regard to the effect of sex on clinical symptoms, concussion-related alterations in brain structure and function, and recovery trajectories. Nonetheless, there is initial evidence to suggest that sex-related differences following concussion are important to consider in efforts to develop objective biomarkers for the diagnosis and prognosis of concussion. Additional studies on this topic are, however, clearly needed to improve our understanding of sex-related differences following concussion, as well as to understand their neurobiological underpinnings. Such studies will help pave the way toward more personalized clinical management and treatment of sports-related concussion. |
format | Online Article Text |
id | pubmed-8221087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-82210872021-07-01 Sex-Related Differences in the Effects of Sports-Related Concussion: A Review Koerte, Inga K. Schultz, Vivian Sydnor, Valerie J. Howell, David R. Guenette, Jeffrey P. Dennis, Emily Kochsiek, Janna Kaufmann, David Sollmann, Nico Mondello, Stefania Shenton, Martha E. Lin, Alexander P. J Neuroimaging Article Sports-related concussion is a serious health challenge, and females are at higher risk of sustaining a sports-related concussion compared to males. Although there are many studies that investigate outcomes following concussion, females remain an understudied population, despite representing a large proportion of the organized sports community. In this review, we provide a summary of studies that investigate sex-related differences in outcome following sports-related concussion. Moreover, we provide an introduction to the methods used to study sex-related differences after sports-related concussion, including common clinical and cognitive measures, neuroimaging techniques, as well as biomarkers. A literature search inclusive of articles published to March 2020 was performed using PubMed. The studies were reviewed and discussed with regard to the methods used. Findings from these studies remain mixed with regard to the effect of sex on clinical symptoms, concussion-related alterations in brain structure and function, and recovery trajectories. Nonetheless, there is initial evidence to suggest that sex-related differences following concussion are important to consider in efforts to develop objective biomarkers for the diagnosis and prognosis of concussion. Additional studies on this topic are, however, clearly needed to improve our understanding of sex-related differences following concussion, as well as to understand their neurobiological underpinnings. Such studies will help pave the way toward more personalized clinical management and treatment of sports-related concussion. 2020-06-13 2020-07 /pmc/articles/PMC8221087/ /pubmed/32533752 http://dx.doi.org/10.1111/jon.12726 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Article Koerte, Inga K. Schultz, Vivian Sydnor, Valerie J. Howell, David R. Guenette, Jeffrey P. Dennis, Emily Kochsiek, Janna Kaufmann, David Sollmann, Nico Mondello, Stefania Shenton, Martha E. Lin, Alexander P. Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title | Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title_full | Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title_fullStr | Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title_full_unstemmed | Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title_short | Sex-Related Differences in the Effects of Sports-Related Concussion: A Review |
title_sort | sex-related differences in the effects of sports-related concussion: a review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221087/ https://www.ncbi.nlm.nih.gov/pubmed/32533752 http://dx.doi.org/10.1111/jon.12726 |
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