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Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine
PURPOSE: Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and manag...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221097/ https://www.ncbi.nlm.nih.gov/pubmed/34164797 http://dx.doi.org/10.1007/s42770-021-00533-z |
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author | Shetty, Seema Kouskouti, Christina Schoen, Uwe Evangelatos, Nikolaos Vishwanath, Shashidhar Satyamoorthy, Kapaettu Kainer, Franz Brand, Angela |
author_facet | Shetty, Seema Kouskouti, Christina Schoen, Uwe Evangelatos, Nikolaos Vishwanath, Shashidhar Satyamoorthy, Kapaettu Kainer, Franz Brand, Angela |
author_sort | Shetty, Seema |
collection | PubMed |
description | PURPOSE: Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and management of these infections could play a decisive role in controlling this public health burden. The objective of this review is to provide an insight into the evolution of diagnostic methods for CT infections through the development of new molecular technologies, emphasizing on -omics’ technologies and their significance as diagnostic tools both for effective patient management and control of disease transmission. METHODS: Narrative review of the diagnostic methodologies of CT infections and the impact of the introduction of -omics’ technologies on their diagnosis by review of the literature. RESULTS: Various methodologies are discussed with respect to working principles, required specifications, advantages, and disadvantages. Implementing the most accurate methods in diagnosis is highlighted as the cornerstone in managing CT infections. CONCLUSION: Diagnostics based on -omics’ technologies are considered to be the most pertinent modalities in CT testing when compared to other available methods. There is a need to modify these effective and accurate diagnostic tools in order to render them more available and feasible in all settings, especially aiming on turning them to rapid point-of-care tests for effective patient management and disease control. |
format | Online Article Text |
id | pubmed-8221097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-82210972021-06-23 Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine Shetty, Seema Kouskouti, Christina Schoen, Uwe Evangelatos, Nikolaos Vishwanath, Shashidhar Satyamoorthy, Kapaettu Kainer, Franz Brand, Angela Braz J Microbiol Clinical Microbiology - Review PURPOSE: Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and management of these infections could play a decisive role in controlling this public health burden. The objective of this review is to provide an insight into the evolution of diagnostic methods for CT infections through the development of new molecular technologies, emphasizing on -omics’ technologies and their significance as diagnostic tools both for effective patient management and control of disease transmission. METHODS: Narrative review of the diagnostic methodologies of CT infections and the impact of the introduction of -omics’ technologies on their diagnosis by review of the literature. RESULTS: Various methodologies are discussed with respect to working principles, required specifications, advantages, and disadvantages. Implementing the most accurate methods in diagnosis is highlighted as the cornerstone in managing CT infections. CONCLUSION: Diagnostics based on -omics’ technologies are considered to be the most pertinent modalities in CT testing when compared to other available methods. There is a need to modify these effective and accurate diagnostic tools in order to render them more available and feasible in all settings, especially aiming on turning them to rapid point-of-care tests for effective patient management and disease control. Springer International Publishing 2021-06-23 /pmc/articles/PMC8221097/ /pubmed/34164797 http://dx.doi.org/10.1007/s42770-021-00533-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Clinical Microbiology - Review Shetty, Seema Kouskouti, Christina Schoen, Uwe Evangelatos, Nikolaos Vishwanath, Shashidhar Satyamoorthy, Kapaettu Kainer, Franz Brand, Angela Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title | Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title_full | Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title_fullStr | Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title_full_unstemmed | Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title_short | Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine |
title_sort | diagnosis of chlamydia trachomatis genital infections in the era of genomic medicine |
topic | Clinical Microbiology - Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221097/ https://www.ncbi.nlm.nih.gov/pubmed/34164797 http://dx.doi.org/10.1007/s42770-021-00533-z |
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