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Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity

Myocardial fibrosis is considered a key pathological process in the development of cardiovascular diseases. In epicardial obesity (EO), the main cause of fibrosis development is lipotoxic myocardial damage. It is important to detect myocardial fibrosis at an early stage, using non-invasive diagnosti...

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Autores principales: Chumakova, Galina, Gritsenko, Olesya, Gruzdeva, Olga, Dyleva, Yulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221350/
https://www.ncbi.nlm.nih.gov/pubmed/34088886
http://dx.doi.org/10.18632/aging.203148
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author Chumakova, Galina
Gritsenko, Olesya
Gruzdeva, Olga
Dyleva, Yulia
author_facet Chumakova, Galina
Gritsenko, Olesya
Gruzdeva, Olga
Dyleva, Yulia
author_sort Chumakova, Galina
collection PubMed
description Myocardial fibrosis is considered a key pathological process in the development of cardiovascular diseases. In epicardial obesity (EO), the main cause of fibrosis development is lipotoxic myocardial damage. It is important to detect myocardial fibrosis at an early stage, using non-invasive diagnostic methods. According to the results of echocardiography (ECG), 110 men with general obesity were divided into the following two groups: Group I with epicardial fat thickness (tEAT) ≥ 7 mm (n = 70) and Group II with tEAT < 7 mm (n = 40) without diastolic dysfunction. The levels of metabolic factors, pro-inflammatory cytokines, adipokines, and free fatty acids (FFA), profibrotic markers were determined in both groups. In Group I, the level of interleukin (IL)-6, C-reactive protein, and tumor necrosis factor (TNF)-α increased and that of leptin and adiponectin decreased compared with those in Group II. There was an increase in the level of all studied profibrotic factors in Group I. The level of TNF-α and IL-6 showed a positive correlation with the level of leptin and FFA and a negative correlation with the level of adiponectin. We also observed a relationship between the level of collagen, transforming growth factor (TGF)-β, and metalloproteinase (MMP)-3 and EO. Our results showed that confirmed EO correlates with not only disadipocytosis and increased levels of pro-inflammatory cytokines, but also increased levels of profibrotic factors. This suggests that the studied markers of fibrosis may be used to determine preclinical cardiac fibrosis with lipotoxic myocardial damage in patients with EO.
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spelling pubmed-82213502021-06-26 Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity Chumakova, Galina Gritsenko, Olesya Gruzdeva, Olga Dyleva, Yulia Aging (Albany NY) Research Paper Myocardial fibrosis is considered a key pathological process in the development of cardiovascular diseases. In epicardial obesity (EO), the main cause of fibrosis development is lipotoxic myocardial damage. It is important to detect myocardial fibrosis at an early stage, using non-invasive diagnostic methods. According to the results of echocardiography (ECG), 110 men with general obesity were divided into the following two groups: Group I with epicardial fat thickness (tEAT) ≥ 7 mm (n = 70) and Group II with tEAT < 7 mm (n = 40) without diastolic dysfunction. The levels of metabolic factors, pro-inflammatory cytokines, adipokines, and free fatty acids (FFA), profibrotic markers were determined in both groups. In Group I, the level of interleukin (IL)-6, C-reactive protein, and tumor necrosis factor (TNF)-α increased and that of leptin and adiponectin decreased compared with those in Group II. There was an increase in the level of all studied profibrotic factors in Group I. The level of TNF-α and IL-6 showed a positive correlation with the level of leptin and FFA and a negative correlation with the level of adiponectin. We also observed a relationship between the level of collagen, transforming growth factor (TGF)-β, and metalloproteinase (MMP)-3 and EO. Our results showed that confirmed EO correlates with not only disadipocytosis and increased levels of pro-inflammatory cytokines, but also increased levels of profibrotic factors. This suggests that the studied markers of fibrosis may be used to determine preclinical cardiac fibrosis with lipotoxic myocardial damage in patients with EO. Impact Journals 2021-06-04 /pmc/articles/PMC8221350/ /pubmed/34088886 http://dx.doi.org/10.18632/aging.203148 Text en Copyright: © 2021 Chumakova et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chumakova, Galina
Gritsenko, Olesya
Gruzdeva, Olga
Dyleva, Yulia
Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title_full Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title_fullStr Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title_full_unstemmed Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title_short Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
title_sort analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221350/
https://www.ncbi.nlm.nih.gov/pubmed/34088886
http://dx.doi.org/10.18632/aging.203148
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