Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation

Intermittent hypoxia (IH)-associated cognition decline is related to the neuroinflammation of microglia. SUMOylation is a post-translational modification related to multiple human diseases, which can be reversed by SENP1. Studies showed that SENP1 and PPARγ play essential roles in restricting inflam...

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Detalles Bibliográficos
Autores principales: Wang, Hongwei, Xiong, Wei, Hang, Sitong, Wang, Yanmin, Zhang, Sisen, Liu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221356/
https://www.ncbi.nlm.nih.gov/pubmed/34035184
http://dx.doi.org/10.18632/aging.203084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221356/
https://www.ncbi.nlm.nih.gov/pubmed/34035184
http://dx.doi.org/10.18632/aging.203084

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