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The human microbiome and COVID-19: A systematic review

BACKGROUND: Human microbiotas are communities of microorganisms living in symbiosis with humans. They play an important role in the host immune response to respiratory viral infection. However, evidence on the human microbiome and coronavirus disease (COVID-19) relationship is insufficient. The aim...

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Autores principales: Yamamoto, Shinya, Saito, Makoto, Tamura, Azumi, Prawisuda, Diki, Mizutani, Taketoshi, Yotsuyanagi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221462/
https://www.ncbi.nlm.nih.gov/pubmed/34161373
http://dx.doi.org/10.1371/journal.pone.0253293
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author Yamamoto, Shinya
Saito, Makoto
Tamura, Azumi
Prawisuda, Diki
Mizutani, Taketoshi
Yotsuyanagi, Hiroshi
author_facet Yamamoto, Shinya
Saito, Makoto
Tamura, Azumi
Prawisuda, Diki
Mizutani, Taketoshi
Yotsuyanagi, Hiroshi
author_sort Yamamoto, Shinya
collection PubMed
description BACKGROUND: Human microbiotas are communities of microorganisms living in symbiosis with humans. They play an important role in the host immune response to respiratory viral infection. However, evidence on the human microbiome and coronavirus disease (COVID-19) relationship is insufficient. The aim of this systematic literature review was to evaluate existing evidence on the association between the microbiome and COVID-19 in humans and summarize these data in the pandemic era. METHODS: We conducted a systematic literature review on the association between the microbiome and COVID-19 in humans by searching PubMed, Embase, and the Cochrane Library, CINAHL, and Web of Science databases for articles in English published up to October 31, 2020. The results were analyzed qualitatively. This study is registered with PROSPERO (CRD42020195982). RESULTS: Of the 543 articles identified by searching databases, 16 in line with the research objectives were eligible for qualitative review: eight sampled the microbiome using stool, four using nasopharyngeal or throat swab, three using bronchoalveolar lavage fluid, and one using lung tissue. Fecal microbiome dysbiosis and increased opportunistic pathogens were reported in COVID-19 patients. Several studies suggested the dysbiosis in the lung microbiome of COVID-19 patients with an abundance of opportunistic pathogens using lower respiratory tract samples. The association between COVID-19 severity and the human microbiome remains uncertain. CONCLUSION: The human fecal and respiratory tract microbiome changed in COVID-19 patients with opportunistic pathogen abundance. Further research to elucidate the effect of alternation of the human microbiome in disease pathogenesis is warranted.
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spelling pubmed-82214622021-07-07 The human microbiome and COVID-19: A systematic review Yamamoto, Shinya Saito, Makoto Tamura, Azumi Prawisuda, Diki Mizutani, Taketoshi Yotsuyanagi, Hiroshi PLoS One Research Article BACKGROUND: Human microbiotas are communities of microorganisms living in symbiosis with humans. They play an important role in the host immune response to respiratory viral infection. However, evidence on the human microbiome and coronavirus disease (COVID-19) relationship is insufficient. The aim of this systematic literature review was to evaluate existing evidence on the association between the microbiome and COVID-19 in humans and summarize these data in the pandemic era. METHODS: We conducted a systematic literature review on the association between the microbiome and COVID-19 in humans by searching PubMed, Embase, and the Cochrane Library, CINAHL, and Web of Science databases for articles in English published up to October 31, 2020. The results were analyzed qualitatively. This study is registered with PROSPERO (CRD42020195982). RESULTS: Of the 543 articles identified by searching databases, 16 in line with the research objectives were eligible for qualitative review: eight sampled the microbiome using stool, four using nasopharyngeal or throat swab, three using bronchoalveolar lavage fluid, and one using lung tissue. Fecal microbiome dysbiosis and increased opportunistic pathogens were reported in COVID-19 patients. Several studies suggested the dysbiosis in the lung microbiome of COVID-19 patients with an abundance of opportunistic pathogens using lower respiratory tract samples. The association between COVID-19 severity and the human microbiome remains uncertain. CONCLUSION: The human fecal and respiratory tract microbiome changed in COVID-19 patients with opportunistic pathogen abundance. Further research to elucidate the effect of alternation of the human microbiome in disease pathogenesis is warranted. Public Library of Science 2021-06-23 /pmc/articles/PMC8221462/ /pubmed/34161373 http://dx.doi.org/10.1371/journal.pone.0253293 Text en © 2021 Yamamoto et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamamoto, Shinya
Saito, Makoto
Tamura, Azumi
Prawisuda, Diki
Mizutani, Taketoshi
Yotsuyanagi, Hiroshi
The human microbiome and COVID-19: A systematic review
title The human microbiome and COVID-19: A systematic review
title_full The human microbiome and COVID-19: A systematic review
title_fullStr The human microbiome and COVID-19: A systematic review
title_full_unstemmed The human microbiome and COVID-19: A systematic review
title_short The human microbiome and COVID-19: A systematic review
title_sort human microbiome and covid-19: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221462/
https://www.ncbi.nlm.nih.gov/pubmed/34161373
http://dx.doi.org/10.1371/journal.pone.0253293
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