Cargando…

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient than PARG against poly(ADP-ribose) (PAR) chains in vitro. Her...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prokhorova, Evgeniia, Agnew, Thomas, Wondisford, Anne R., Tellier, Michael, Kaminski, Nicole, Beijer, Danique, Holder, James, Groslambert, Josephine, Suskiewicz, Marcin J., Zhu, Kang, Reber, Julia M., Krassnig, Sarah C., Palazzo, Luca, Murphy, Shona, Nielsen, Michael L., Mangerich, Aswin, Ahel, Dragana, Baets, Jonathan, O’Sullivan, Roderick J., Ahel, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221567/ https://www.ncbi.nlm.nih.gov/pubmed/34019811 http://dx.doi.org/10.1016/j.molcel.2021.04.028

Ejemplares similares

ADP-ribosylation of DNA and RNA()
por: Groslambert, Joséphine, et al.
Publicado: (2021)

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
por: Beijer, Danique, et al.
Publicado: (2021)

Serine is the major residue for ADP-ribosylation upon DNA damage
por: Palazzo, Luca, et al.
Publicado: (2018)

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2021)

Interplay of Histone Marks with Serine ADP-Ribosylation
por: Bartlett, Edward, et al.
Publicado: (2018)

ADP-ribosylation signalling and human disease
por: Palazzo, Luca, et al.
Publicado: (2019)

(ADP-ribosyl)hydrolases: structure, function, and biology
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2020)

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria
por: Agnew, Thomas, et al.
Publicado: (2018)

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
por: Fontana, Pietro, et al.
Publicado: (2023)

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
por: Đukić, Nina, et al.
Publicado: (2023)

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
por: Suskiewicz, Marcin J., et al.
Publicado: (2020)

Reversible mono‐ADP‐ribosylation of DNA breaks
por: Munnur, Deeksha, et al.
Publicado: (2017)

The function and regulation of ADP-ribosylation in the DNA damage response
por: Duma, Lena, et al.
Publicado: (2023)

Serine ADP-ribosylation reversal by the hydrolase ARH3
por: Fontana, Pietro, et al.
Publicado: (2017)

ADP-ribosylation systems in bacteria and viruses
por: Mikolčević, Petra, et al.
Publicado: (2021)

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA
por: Jankevicius, Gytis, et al.
Publicado: (2016)

Beyond protein modification: the rise of non-canonical ADP-ribosylation
por: Schuller, Marion, et al.
Publicado: (2022)

Serine-linked PARP1 auto-modification controls PARP inhibitor response
por: Prokhorova, Evgeniia, et al.
Publicado: (2021)

Reversible ADP-ribosylation of RNA
por: Munnur, Deeksha, et al.
Publicado: (2019)

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life
por: Perina, Dragutin, et al.
Publicado: (2014)

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
por: Schützenhofer, Kira, et al.
Publicado: (2021)

ENPP1 processes protein ADP‐ribosylation in vitro
por: Palazzo, Luca, et al.
Publicado: (2016)

Serine is a new target residue for endogenous ADP-ribosylation on histones
por: Leidecker, Orsolya, et al.
Publicado: (2016)

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
por: Hendriks, Ivo A., et al.
Publicado: (2021)

TARG1 protects against toxic DNA ADP-ribosylation
por: Tromans-Coia, Callum, et al.
Publicado: (2021)

Serine ADP-Ribosylation Depends on HPF1
por: Bonfiglio, Juan José, et al.
Publicado: (2017)

Molecular Tools for the Study of ADP‐Ribosylation: A Unified and Versatile Method to Synthesise Native Mono‐ADP‐Ribosylated Peptides
por: Voorneveld, Jim, et al.
Publicado: (2021)

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2018)

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
por: Gunn, Alasdair R., et al.
Publicado: (2016)

Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)
por: Reber, Julia M, et al.
Publicado: (2021)

Mimetics of ADP-Ribosylated Histidine through Copper(I)-Catalyzed Click Chemistry
por: Minnee, Hugo, et al.
Publicado: (2022)

DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair
por: Lawarée, Emeline, et al.
Publicado: (2019)

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
por: Gibbs-Seymour, Ian, et al.
Publicado: (2016)

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer
por: Voorneveld, Jim, et al.
Publicado: (2018)

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2015)

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA
por: Hloušek-Kasun, Andrea, et al.
Publicado: (2022)

Targeting ADP-ribosylation as an antimicrobial strategy
por: Catara, Giuliana, et al.
Publicado: (2019)

Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
por: Longarini, Edoardo José, et al.
Publicado: (2023)

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
por: Munnur, Deeksha, et al.
Publicado: (2019)

ADP-ribosylation of arginine
por: Laing, Sabrina, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_cfh45cg3vmid3secbs2o21uiak