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The American lobster genome reveals insights on longevity, neural, and immune adaptations

The American lobster, Homarus americanus, is integral to marine ecosystems and supports an important commercial fishery. This iconic species also serves as a valuable model for deciphering neural networks controlling rhythmic motor patterns and olfaction. Here, we report a high-quality draft assembl...

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Autores principales: Polinski, Jennifer M., Zimin, Aleksey V., Clark, K. Fraser, Kohn, Andrea B., Sadowski, Norah, Timp, Winston, Ptitsyn, Andrey, Khanna, Prarthana, Romanova, Daria Y., Williams, Peter, Greenwood, Spencer J., Moroz, Leonid L., Walt, David R., Bodnar, Andrea G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221624/
https://www.ncbi.nlm.nih.gov/pubmed/34162536
http://dx.doi.org/10.1126/sciadv.abe8290
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author Polinski, Jennifer M.
Zimin, Aleksey V.
Clark, K. Fraser
Kohn, Andrea B.
Sadowski, Norah
Timp, Winston
Ptitsyn, Andrey
Khanna, Prarthana
Romanova, Daria Y.
Williams, Peter
Greenwood, Spencer J.
Moroz, Leonid L.
Walt, David R.
Bodnar, Andrea G.
author_facet Polinski, Jennifer M.
Zimin, Aleksey V.
Clark, K. Fraser
Kohn, Andrea B.
Sadowski, Norah
Timp, Winston
Ptitsyn, Andrey
Khanna, Prarthana
Romanova, Daria Y.
Williams, Peter
Greenwood, Spencer J.
Moroz, Leonid L.
Walt, David R.
Bodnar, Andrea G.
author_sort Polinski, Jennifer M.
collection PubMed
description The American lobster, Homarus americanus, is integral to marine ecosystems and supports an important commercial fishery. This iconic species also serves as a valuable model for deciphering neural networks controlling rhythmic motor patterns and olfaction. Here, we report a high-quality draft assembly of the H. americanus genome with 25,284 predicted gene models. Analysis of the neural gene complement revealed extraordinary development of the chemosensory machinery, including a profound diversification of ligand-gated ion channels and secretory molecules. The discovery of a novel class of chimeric receptors coupling pattern recognition and neurotransmitter binding suggests a deep integration between the neural and immune systems. A robust repertoire of genes involved in innate immunity, genome stability, cell survival, chemical defense, and cuticle formation represents a diversity of defense mechanisms essential to thrive in the benthic marine environment. Together, these unique evolutionary adaptations contribute to the longevity and ecological success of this long-lived benthic predator.
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spelling pubmed-82216242021-07-01 The American lobster genome reveals insights on longevity, neural, and immune adaptations Polinski, Jennifer M. Zimin, Aleksey V. Clark, K. Fraser Kohn, Andrea B. Sadowski, Norah Timp, Winston Ptitsyn, Andrey Khanna, Prarthana Romanova, Daria Y. Williams, Peter Greenwood, Spencer J. Moroz, Leonid L. Walt, David R. Bodnar, Andrea G. Sci Adv Research Articles The American lobster, Homarus americanus, is integral to marine ecosystems and supports an important commercial fishery. This iconic species also serves as a valuable model for deciphering neural networks controlling rhythmic motor patterns and olfaction. Here, we report a high-quality draft assembly of the H. americanus genome with 25,284 predicted gene models. Analysis of the neural gene complement revealed extraordinary development of the chemosensory machinery, including a profound diversification of ligand-gated ion channels and secretory molecules. The discovery of a novel class of chimeric receptors coupling pattern recognition and neurotransmitter binding suggests a deep integration between the neural and immune systems. A robust repertoire of genes involved in innate immunity, genome stability, cell survival, chemical defense, and cuticle formation represents a diversity of defense mechanisms essential to thrive in the benthic marine environment. Together, these unique evolutionary adaptations contribute to the longevity and ecological success of this long-lived benthic predator. American Association for the Advancement of Science 2021-06-23 /pmc/articles/PMC8221624/ /pubmed/34162536 http://dx.doi.org/10.1126/sciadv.abe8290 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Polinski, Jennifer M.
Zimin, Aleksey V.
Clark, K. Fraser
Kohn, Andrea B.
Sadowski, Norah
Timp, Winston
Ptitsyn, Andrey
Khanna, Prarthana
Romanova, Daria Y.
Williams, Peter
Greenwood, Spencer J.
Moroz, Leonid L.
Walt, David R.
Bodnar, Andrea G.
The American lobster genome reveals insights on longevity, neural, and immune adaptations
title The American lobster genome reveals insights on longevity, neural, and immune adaptations
title_full The American lobster genome reveals insights on longevity, neural, and immune adaptations
title_fullStr The American lobster genome reveals insights on longevity, neural, and immune adaptations
title_full_unstemmed The American lobster genome reveals insights on longevity, neural, and immune adaptations
title_short The American lobster genome reveals insights on longevity, neural, and immune adaptations
title_sort american lobster genome reveals insights on longevity, neural, and immune adaptations
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221624/
https://www.ncbi.nlm.nih.gov/pubmed/34162536
http://dx.doi.org/10.1126/sciadv.abe8290
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