Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ

Mutation of ciliopathy protein HYLS1 causes the perinatal lethal hydrolethalus syndrome (HLS), yet the underlying molecular etiology and pathogenesis remain elusive. Here, we reveal unexpected mechanistic insights into the role of mammalian HYLS1 in regulating primary cilia. HYLS1 is recruited to th...

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Detalles Bibliográficos
Autores principales: Chen, Chuan, Xu, Qingwen, Zhang, Yuxia, Davies, Brian A., Huang, Yan, Katzmann, David J., Harris, Peter C., Hu, Jinghua, Ling, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221637/
https://www.ncbi.nlm.nih.gov/pubmed/34162535
http://dx.doi.org/10.1126/sciadv.abe3401

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