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Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs

Rab11 GTPase proteins are required for cytokinesis, ciliogenesis, and lumenogenesis. Rab11a is critical for apical delivery of podocalyxin (PODXL) during lumen formation in epithelial cells. SH3BP5 and SH3BP5L are guanine nucleotide exchange factors (GEFs) for Rab11. We show that SH3BP5 and SH3BP5L...

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Detalles Bibliográficos
Autores principales:	Chandrakumar, Arun A., Coyaud, Étienne, Marshall, Christopher B., Ikura, Mitsuhiko, Raught, Brian, Rottapel, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221736/ https://www.ncbi.nlm.nih.gov/pubmed/34128958 http://dx.doi.org/10.1083/jcb.202008037

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