Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non-cancerous OXPHOS and thus suffer from a limited th...

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Detalles Bibliográficos
Autores principales: Nelson, Margaret AM, McLaughlin, Kelsey L, Hagen, James T, Coalson, Hannah S, Schmidt, Cameron, Kassai, Miki, Kew, Kimberly A, McClung, Joseph M, Neufer, P Darrell, Brophy, Patricia, Vohra, Nasreen A, Liles, Darla, Cabot, Myles C, Fisher-Wellman, Kelsey H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221809/
https://www.ncbi.nlm.nih.gov/pubmed/34132194
http://dx.doi.org/10.7554/eLife.63104

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