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Visual intracortical and transthalamic pathways carry distinct information to cortical areas

Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of...

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Autores principales: Blot, Antonin, Roth, Morgane M., Gasler, Ioana, Javadzadeh, Mitra, Imhof, Fabia, Hofer, Sonja B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221812/
https://www.ncbi.nlm.nih.gov/pubmed/33979633
http://dx.doi.org/10.1016/j.neuron.2021.04.017
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author Blot, Antonin
Roth, Morgane M.
Gasler, Ioana
Javadzadeh, Mitra
Imhof, Fabia
Hofer, Sonja B.
author_facet Blot, Antonin
Roth, Morgane M.
Gasler, Ioana
Javadzadeh, Mitra
Imhof, Fabia
Hofer, Sonja B.
author_sort Blot, Antonin
collection PubMed
description Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context.
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spelling pubmed-82218122021-06-29 Visual intracortical and transthalamic pathways carry distinct information to cortical areas Blot, Antonin Roth, Morgane M. Gasler, Ioana Javadzadeh, Mitra Imhof, Fabia Hofer, Sonja B. Neuron Article Sensory processing involves information flow between neocortical areas, assumed to rely on direct intracortical projections. However, cortical areas may also communicate indirectly via higher-order nuclei in the thalamus, such as the pulvinar or lateral posterior nucleus (LP) in the visual system of rodents. The fine-scale organization and function of these cortico-thalamo-cortical pathways remains unclear. We find that responses of mouse LP neurons projecting to higher visual areas likely derive from feedforward input from primary visual cortex (V1) combined with information from many cortical and subcortical areas, including superior colliculus. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context, distinct from the signals carried by direct intracortical projections from V1. Thus, visual transthalamic pathways are functionally specific to their cortical target, different from feedforward cortical pathways, and combine information from multiple brain regions, linking sensory signals with behavioral context. Cell Press 2021-06-16 /pmc/articles/PMC8221812/ /pubmed/33979633 http://dx.doi.org/10.1016/j.neuron.2021.04.017 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blot, Antonin
Roth, Morgane M.
Gasler, Ioana
Javadzadeh, Mitra
Imhof, Fabia
Hofer, Sonja B.
Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title_full Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title_fullStr Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title_full_unstemmed Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title_short Visual intracortical and transthalamic pathways carry distinct information to cortical areas
title_sort visual intracortical and transthalamic pathways carry distinct information to cortical areas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221812/
https://www.ncbi.nlm.nih.gov/pubmed/33979633
http://dx.doi.org/10.1016/j.neuron.2021.04.017
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