RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness

Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs) and mediates mammary tumor initiation. Mammary tumors initiated by oncogenes or carcinogen exposure display high levels of Rank and Rank pathway inhibitors have emerged as a new strategy for breast cancer prevention...

Descripción completa

Detalles Bibliográficos
Autores principales: Benítez, Sandra, Cordero, Alex, Santamaría, Patricia G., Redondo-Pedraza, Jaime, Rocha, Ana S., Collado-Solé, Alejandro, Jimenez, Maria, Sanz-Moreno, Adrian, Yoldi, Guillermo, Santos, Juliana C., De Benedictis, Ilaria, Gómez-Aleza, Clara, Da Silva-Álvarez, Sabela, Troulé, Kevin, Gómez-López, Gonzalo, Alcazar, Noelia, Palmero, Ignacio, Collado, Manuel, Serrano, Manuel, Gonzalez-Suarez, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221814/
https://www.ncbi.nlm.nih.gov/pubmed/34004159
http://dx.doi.org/10.1016/j.devcel.2021.04.022

Ejemplares similares

Ejemplares similares