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Approximate image synthesis in optical coherence tomography

Full-wave models of OCT image formation, which are based on Maxwell’s equations, are highly realistic. However, such models incur a high computational cost, particularly when modelling sample volumes consistent with those encountered in practice. Here, we present an approximate means of synthesizing...

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Detalles Bibliográficos
Autores principales: Macdonald, Callum M., Munro, Peter R. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221936/
https://www.ncbi.nlm.nih.gov/pubmed/34221663
http://dx.doi.org/10.1364/BOE.420992
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author Macdonald, Callum M.
Munro, Peter R. T.
author_facet Macdonald, Callum M.
Munro, Peter R. T.
author_sort Macdonald, Callum M.
collection PubMed
description Full-wave models of OCT image formation, which are based on Maxwell’s equations, are highly realistic. However, such models incur a high computational cost, particularly when modelling sample volumes consistent with those encountered in practice. Here, we present an approximate means of synthesizing volumetric image formation to reduce this computational burden. Instead of performing a full-wave scattered light calculation for each A-scan, we perform a full-wave scattered light calculation for a normally incident plane wave only. We use the angular spectrum field representation to implement beam focussing and scanning, making use of an assumption similar to the tilt optical memory effect, to approximately synthesize volumetric data sets. Our approach leads to an order of magnitude reduction in the computation time required to simulate typical B-scans. We evaluate this method by comparing rigorously and approximately evaluated point spread functions and images of highly scattering structured samples for a typical OCT system. Our approach also reveals new insights into image formation in OCT.
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spelling pubmed-82219362021-07-01 Approximate image synthesis in optical coherence tomography Macdonald, Callum M. Munro, Peter R. T. Biomed Opt Express Article Full-wave models of OCT image formation, which are based on Maxwell’s equations, are highly realistic. However, such models incur a high computational cost, particularly when modelling sample volumes consistent with those encountered in practice. Here, we present an approximate means of synthesizing volumetric image formation to reduce this computational burden. Instead of performing a full-wave scattered light calculation for each A-scan, we perform a full-wave scattered light calculation for a normally incident plane wave only. We use the angular spectrum field representation to implement beam focussing and scanning, making use of an assumption similar to the tilt optical memory effect, to approximately synthesize volumetric data sets. Our approach leads to an order of magnitude reduction in the computation time required to simulate typical B-scans. We evaluate this method by comparing rigorously and approximately evaluated point spread functions and images of highly scattering structured samples for a typical OCT system. Our approach also reveals new insights into image formation in OCT. Optical Society of America 2021-05-12 /pmc/articles/PMC8221936/ /pubmed/34221663 http://dx.doi.org/10.1364/BOE.420992 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Macdonald, Callum M.
Munro, Peter R. T.
Approximate image synthesis in optical coherence tomography
title Approximate image synthesis in optical coherence tomography
title_full Approximate image synthesis in optical coherence tomography
title_fullStr Approximate image synthesis in optical coherence tomography
title_full_unstemmed Approximate image synthesis in optical coherence tomography
title_short Approximate image synthesis in optical coherence tomography
title_sort approximate image synthesis in optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221936/
https://www.ncbi.nlm.nih.gov/pubmed/34221663
http://dx.doi.org/10.1364/BOE.420992
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