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The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience

BACKGROUND: The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). MATERIAL...

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Autores principales: Benfante, Alida, Messina, Riccardo, Piccionello, Ilaria, Di Liberti, Rosangela, Principe, Stefania, Scichilone, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221991/
https://www.ncbi.nlm.nih.gov/pubmed/33965569
http://dx.doi.org/10.1016/j.pupt.2021.102038
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author Benfante, Alida
Messina, Riccardo
Piccionello, Ilaria
Di Liberti, Rosangela
Principe, Stefania
Scichilone, Nicola
author_facet Benfante, Alida
Messina, Riccardo
Piccionello, Ilaria
Di Liberti, Rosangela
Principe, Stefania
Scichilone, Nicola
author_sort Benfante, Alida
collection PubMed
description BACKGROUND: The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). MATERIAL AND METHODS: We conducted a retrospective observational analysis including IPF patients under antifibrotic drugs (nintedanib and pirfenidone) that accessed to the Outpatient clinic of the University of Palermo, Italy. Patients received a phone number and an email address in case of any urgency and a virtual meeting was settled up monthly. RESULTS: 40 patients (M/F: 30/10) were followed up, 33 under nintedanib treatment, 7 under pirfenidone. Among patients under nintedanib, 1 patient reported high fever (T max 39 °C) and purulent sputum with no sign of infections, 1 had hemoptysis that was spontaneously resolved. 2 patients accessed to the emergency department for the worsening of dyspnea; 5 patients had diarrhea that resolved with symptomatic drugs in few days. 3 patients had an increase of alkaline phosphatase levels, leading to the withdrawal of the antifibrotic drug for 15 days, and subsequent normalization of the plasmatic levels. Among patients under pirfenidone, one subject had an increase of ferritin serum levels with no symptoms. The remaining subjects were in stable clinical conditions. None of the patients reported hospitalization or exacerbations, and did not experience antifibrotic withdrawal. CONCLUSIONS: We were able to demonstrate that by implementing alternative ways to monitor the disease, patients did not incur in increased rates of acute exacerbations or higher frequency of side effects and antifibrotic treatment withdrawal.
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spelling pubmed-82219912021-06-25 The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience Benfante, Alida Messina, Riccardo Piccionello, Ilaria Di Liberti, Rosangela Principe, Stefania Scichilone, Nicola Pulm Pharmacol Ther Article BACKGROUND: The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). MATERIAL AND METHODS: We conducted a retrospective observational analysis including IPF patients under antifibrotic drugs (nintedanib and pirfenidone) that accessed to the Outpatient clinic of the University of Palermo, Italy. Patients received a phone number and an email address in case of any urgency and a virtual meeting was settled up monthly. RESULTS: 40 patients (M/F: 30/10) were followed up, 33 under nintedanib treatment, 7 under pirfenidone. Among patients under nintedanib, 1 patient reported high fever (T max 39 °C) and purulent sputum with no sign of infections, 1 had hemoptysis that was spontaneously resolved. 2 patients accessed to the emergency department for the worsening of dyspnea; 5 patients had diarrhea that resolved with symptomatic drugs in few days. 3 patients had an increase of alkaline phosphatase levels, leading to the withdrawal of the antifibrotic drug for 15 days, and subsequent normalization of the plasmatic levels. Among patients under pirfenidone, one subject had an increase of ferritin serum levels with no symptoms. The remaining subjects were in stable clinical conditions. None of the patients reported hospitalization or exacerbations, and did not experience antifibrotic withdrawal. CONCLUSIONS: We were able to demonstrate that by implementing alternative ways to monitor the disease, patients did not incur in increased rates of acute exacerbations or higher frequency of side effects and antifibrotic treatment withdrawal. Published by Elsevier Ltd. 2021-08 2021-06-24 /pmc/articles/PMC8221991/ /pubmed/33965569 http://dx.doi.org/10.1016/j.pupt.2021.102038 Text en © 2021 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Benfante, Alida
Messina, Riccardo
Piccionello, Ilaria
Di Liberti, Rosangela
Principe, Stefania
Scichilone, Nicola
The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title_full The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title_fullStr The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title_full_unstemmed The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title_short The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
title_sort impact of sars-cov2 pandemic on the management of ipf patients: our narrative experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221991/
https://www.ncbi.nlm.nih.gov/pubmed/33965569
http://dx.doi.org/10.1016/j.pupt.2021.102038
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