Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature

Basic and clinical research have shown that the expression of molecules involved in the hepatocellular carcinoma (HCC) cell signaling pathway is related to the sensitivity to molecular-targeted agents. We herein report a case of HCC that was effectively treated with lenvatinib after a poor response...

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Autores principales: Shibata, Osamu, Kamimura, Kenya, Ko, Masayoshi, Sakai, Norihiro, Abe, Hiroyuki, Morita, Shinichi, Mizusawa, Takeshi, Sato, Hiroki, Sakamaki, Akira, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222122/
https://www.ncbi.nlm.nih.gov/pubmed/33390501
http://dx.doi.org/10.2169/internalmedicine.6580-20
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author Shibata, Osamu
Kamimura, Kenya
Ko, Masayoshi
Sakai, Norihiro
Abe, Hiroyuki
Morita, Shinichi
Mizusawa, Takeshi
Sato, Hiroki
Sakamaki, Akira
Terai, Shuji
author_facet Shibata, Osamu
Kamimura, Kenya
Ko, Masayoshi
Sakai, Norihiro
Abe, Hiroyuki
Morita, Shinichi
Mizusawa, Takeshi
Sato, Hiroki
Sakamaki, Akira
Terai, Shuji
author_sort Shibata, Osamu
collection PubMed
description Basic and clinical research have shown that the expression of molecules involved in the hepatocellular carcinoma (HCC) cell signaling pathway is related to the sensitivity to molecular-targeted agents. We herein report a case of HCC that was effectively treated with lenvatinib after a poor response to sorafenib. The tumor showed a high expression of fibroblast growth factor receptor 4, which is reportedly related to the sensitivity to lenvatinib in vitro. The information obtained from this case and from our literature review highlights the importance of assessing the expression of the molecules involved in tumors for effective precision medicine.
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spelling pubmed-82221222021-06-27 Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature Shibata, Osamu Kamimura, Kenya Ko, Masayoshi Sakai, Norihiro Abe, Hiroyuki Morita, Shinichi Mizusawa, Takeshi Sato, Hiroki Sakamaki, Akira Terai, Shuji Intern Med Case Report Basic and clinical research have shown that the expression of molecules involved in the hepatocellular carcinoma (HCC) cell signaling pathway is related to the sensitivity to molecular-targeted agents. We herein report a case of HCC that was effectively treated with lenvatinib after a poor response to sorafenib. The tumor showed a high expression of fibroblast growth factor receptor 4, which is reportedly related to the sensitivity to lenvatinib in vitro. The information obtained from this case and from our literature review highlights the importance of assessing the expression of the molecules involved in tumors for effective precision medicine. The Japanese Society of Internal Medicine 2020-12-29 2021-06-01 /pmc/articles/PMC8222122/ /pubmed/33390501 http://dx.doi.org/10.2169/internalmedicine.6580-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shibata, Osamu
Kamimura, Kenya
Ko, Masayoshi
Sakai, Norihiro
Abe, Hiroyuki
Morita, Shinichi
Mizusawa, Takeshi
Sato, Hiroki
Sakamaki, Akira
Terai, Shuji
Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title_full Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title_fullStr Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title_full_unstemmed Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title_short Effect of Lenvatinib on a Hepatocellular Carcinoma with Fibroblast Growth Factor Receptor 4 Expression: A Case Report and Review of the Literature
title_sort effect of lenvatinib on a hepatocellular carcinoma with fibroblast growth factor receptor 4 expression: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222122/
https://www.ncbi.nlm.nih.gov/pubmed/33390501
http://dx.doi.org/10.2169/internalmedicine.6580-20
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