Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa

A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she...

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Detalles Bibliográficos
Autores principales: Koda, Ryo, Miyazaki, Satoru, Iino, Noriaki, Sato, Yo, Hirano, Kenichiro, Sunami, Eiji, Kosugi, Shinichi, Kanefuji, Tsutomu, Ogose, Akira, Narita, Ichiei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222131/
https://www.ncbi.nlm.nih.gov/pubmed/33390486
http://dx.doi.org/10.2169/internalmedicine.5911-20
Descripción
Sumario:A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.

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