Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review

Ethambutol-induced optic neuropathy (EON) is a well-known complication, although low-dose ethambutol seldom causes EON. An 85-year-old man with non-tuberculous mycobacterial lung disease was taking antibiotics, including low-dose ethambutol. On day 85 of treatment, the diagnosis of EON was made. Des...

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Autores principales: Matsumoto, Takeshi, Kusabiraki, Ryusuke, Arisawa, Akiko, Fujiki, Takahiro, Noda, Akihiro, Tanaka, Ayaka, Yamamoto, Naoki, Aihara, Kensaku, Yamaoka, Shinpachi, Mishima, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222132/
https://www.ncbi.nlm.nih.gov/pubmed/33390493
http://dx.doi.org/10.2169/internalmedicine.6178-20
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author Matsumoto, Takeshi
Kusabiraki, Ryusuke
Arisawa, Akiko
Fujiki, Takahiro
Noda, Akihiro
Tanaka, Ayaka
Yamamoto, Naoki
Aihara, Kensaku
Yamaoka, Shinpachi
Mishima, Michiaki
author_facet Matsumoto, Takeshi
Kusabiraki, Ryusuke
Arisawa, Akiko
Fujiki, Takahiro
Noda, Akihiro
Tanaka, Ayaka
Yamamoto, Naoki
Aihara, Kensaku
Yamaoka, Shinpachi
Mishima, Michiaki
author_sort Matsumoto, Takeshi
collection PubMed
description Ethambutol-induced optic neuropathy (EON) is a well-known complication, although low-dose ethambutol seldom causes EON. An 85-year-old man with non-tuberculous mycobacterial lung disease was taking antibiotics, including low-dose ethambutol. On day 85 of treatment, the diagnosis of EON was made. Despite prior discontinuation, his best corrected visual acuity drastically deteriorated from 20/17 (right eye) and 20/20 (left eye) to 20/330 (right eye) and 20/1,000 (left eye) within 3 weeks, and this symptom did not resolve. To our knowledge, there have been no reported cases with drastically progressing and irreversible EON even after the withdrawal of low-dose and short-term ethambutol.
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spelling pubmed-82221322021-06-27 Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review Matsumoto, Takeshi Kusabiraki, Ryusuke Arisawa, Akiko Fujiki, Takahiro Noda, Akihiro Tanaka, Ayaka Yamamoto, Naoki Aihara, Kensaku Yamaoka, Shinpachi Mishima, Michiaki Intern Med Case Report Ethambutol-induced optic neuropathy (EON) is a well-known complication, although low-dose ethambutol seldom causes EON. An 85-year-old man with non-tuberculous mycobacterial lung disease was taking antibiotics, including low-dose ethambutol. On day 85 of treatment, the diagnosis of EON was made. Despite prior discontinuation, his best corrected visual acuity drastically deteriorated from 20/17 (right eye) and 20/20 (left eye) to 20/330 (right eye) and 20/1,000 (left eye) within 3 weeks, and this symptom did not resolve. To our knowledge, there have been no reported cases with drastically progressing and irreversible EON even after the withdrawal of low-dose and short-term ethambutol. The Japanese Society of Internal Medicine 2020-12-29 2021-06-01 /pmc/articles/PMC8222132/ /pubmed/33390493 http://dx.doi.org/10.2169/internalmedicine.6178-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsumoto, Takeshi
Kusabiraki, Ryusuke
Arisawa, Akiko
Fujiki, Takahiro
Noda, Akihiro
Tanaka, Ayaka
Yamamoto, Naoki
Aihara, Kensaku
Yamaoka, Shinpachi
Mishima, Michiaki
Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title_full Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title_fullStr Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title_full_unstemmed Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title_short Drastically Progressive Ethambutol-induced Optic Neuropathy after Withdrawal of Ethambutol: A Case Report and Literature Review
title_sort drastically progressive ethambutol-induced optic neuropathy after withdrawal of ethambutol: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222132/
https://www.ncbi.nlm.nih.gov/pubmed/33390493
http://dx.doi.org/10.2169/internalmedicine.6178-20
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